IER3
Identifiers
AliasesIER3, DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1, immediate early response 3
External IDsOMIM: 602996 MGI: 104814 HomoloGene: 2894 GeneCards: IER3
Orthologs
SpeciesHumanMouse
Entrez

8870

15937

Ensembl

ENSG00000137331

ENSMUSG00000003541

UniProt

P46695

P46694
Q91VZ5

RefSeq (mRNA)

NM_052815
NM_003897

NM_133662

RefSeq (protein)

NP_003888

NP_598423

Location (UCSC)Chr 6: 30.74 – 30.74 MbChr 17: 36.13 – 36.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene.[5][6]

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000137331 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003541 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kondratyev AD, Chung KN, Jung MO (May 1996). "Identification and characterization of a radiation-inducible glycosylated human early-response gene". Cancer Res. 56 (7): 1498–502. PMID 8603392.
  6. Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF (Aug 1998). "IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival". Science. 281 (5379): 998–1001. Bibcode:1998Sci...281..998W. doi:10.1126/science.281.5379.998. PMID 9703517.
  7. "Entrez Gene: IER3 immediate early response 3".

Further reading

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