IL12A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F45, 3HMX
Identifiers
Aliases	IL12A, CLMF, IL-12A, NFSK, NKSF1, P35, interleukin 12A
External IDs	OMIM: 161560 MGI: 96539 HomoloGene: 681 GeneCards: IL12A
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.33 Start 159,988,835 bp[1] End 159,996,019 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 E1|3 31.92 cM Start 68,597,977 bp[2] End 68,605,880 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube upper lobe of left lung spleen stromal cell of endometrium amygdala bronchial epithelial cell cingulate gyrus lymph node monocyte bone marrow cells Top expressed in knee joint triceps brachii muscle quadriceps femoris muscle skeletal muscle tissue gastrocnemius muscle spleen temporal muscle esophagus blood vastus lateralis muscle More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity interleukin-27 binding interleukin-12 beta subunit binding protein binding protein heterodimerization activity growth factor activity interleukin-12 receptor binding Cellular component cytoplasm interleukin-12 complex extracellular region extracellular space endoplasmic reticulum lumen late endosome lumen cell surface Biological process positive regulation of T cell differentiation negative regulation of smooth muscle cell proliferation extrinsic apoptotic signaling pathway positive regulation of smooth muscle cell apoptotic process response to virus positive regulation of T cell mediated cytotoxicity positive regulation of interferon-gamma production positive regulation of natural killer cell activation positive regulation of NK T cell activation response to lipopolysaccharide positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target immune response response to UV-B cellular response to lipopolysaccharide negative regulation of interleukin-17 production cell migration positive regulation of natural killer cell mediated cytotoxicity positive regulation of lymphocyte proliferation positive regulation of dendritic cell chemotaxis positive regulation of mononuclear cell proliferation positive regulation of cell adhesion defense response to protozoan defense response to Gram-positive bacterium positive regulation of T cell proliferation positive regulation of tyrosine phosphorylation of STAT protein interleukin-12-mediated signaling pathway cell population proliferation regulation of signaling receptor activity T-helper 1 cell cytokine production cytokine-mediated signaling pathway interleukin-35-mediated signaling pathway T-helper 1 cell activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3592 16159 Ensembl ENSG00000168811 ENSMUSG00000027776 UniProt P29459 P43431 RefSeq (mRNA) NM_000882 NM_001354582 NM_001354583 NM_001397992 NM_001159424 NM_008351 RefSeq (protein) NP_000873 NP_001341511 NP_001341512 NP_001152896 NP_032377 Location (UCSC) Chr 3: 159.99 – 160 Mb Chr 3: 68.6 – 68.61 Mb PubMed search [3] [4]
Wikidata
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Interleukin-12 subunit alpha (IL-12 p35) is a protein that in humans is encoded by the IL12A gene.^[5]

Function

This gene encodes a subunit of the cytokine Interleukin 12 (IL-12) that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-dependent induction of interferon gamma (IFN-γ), and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.^[6]

References

Further reading