IL36A

IL36A
Identifiers
Aliases	IL36A, FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6, interleukin 36, alpha, interleukin 36 alpha
External IDs	OMIM: 605509 MGI: 1859324 HomoloGene: 8688 GeneCards: IL36A
Gene location (Human)
Chr.	Chromosome 2 (human)
End	113,008,044 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	24,115,714 bp
RNA expression pattern
	Top expressed in
	epithelium of esophagus; ; cavity of mouth; ; body of tongue; ; pancreatic ductal cell; ; gums; ; thymus; ; vagina; ; cervix epithelium; ; superior surface of tongue; ; minor salivary gland;
	Top expressed in
	esophagus; ; lip; ; cervix; ; right ventricle; ; belly cord; ; temporal muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; submandibular gland; ; otic placode;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-1 receptor binding; cytokine activity;
Cellular component	extracellular region; extracellular space;
Biological process	positive regulation of interleukin-6 production; innate immune response; positive regulation of cytokine production; immune system process; inflammatory response; immune response; regulation of signaling receptor activity; cytokine-mediated signaling pathway; neutrophil chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of JNK cascade; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	27179
	54448
	ENSG00000136694
	ENSMUSG00000026984
	Q9UHA7
	Q9JLA2
	NM_014440
	NM_019450
	NP_055255
	NP_062323
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-36 alpha also known as interleukin-1 family member 6 (IL1F6) is a protein that in humans is encoded by the IL36A gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136694 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026984 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (January 2000). "Four new members expand the interleukin-1 superfamily". The Journal of Biological Chemistry. 275 (2): 1169–1175. doi:10.1074/jbc.275.2.1169. PMID 10625660.
↑ "Entrez Gene: IL1F6 interleukin 1 family, member 6 (epsilon)".

Nicklin MJ, Weith A, Duff GW (January 1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics. 19 (2): 382–384. doi:10.1006/geno.1994.1076. PMID 8188271.
Nothwang HG, Strahm B, Denich D, Kübler M, Schwabe J, Gingrich JC, et al. (May 1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13". Genomics. 41 (3): 370–378. doi:10.1006/geno.1997.4654. PMID 9169134.{{cite journal}}: CS1 maint: overridden setting (link)
Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (October 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochemical and Biophysical Research Communications. 263 (3): 702–706. doi:10.1006/bbrc.1999.1440. PMID 10512743.{{cite journal}}: CS1 maint: overridden setting (link)
Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, et al. (April 2000). "Identification and initial characterization of four novel members of the interleukin-1 family". The Journal of Biological Chemistry. 275 (14): 10308–10314. doi:10.1074/jbc.275.14.10308. PMID 10744718.{{cite journal}}: CS1 maint: overridden setting (link)
Busfield SJ, Comrack CA, Yu G, Chickering TW, Smutko JS, Zhou H, et al. (June 2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics. 66 (2): 213–216. doi:10.1006/geno.2000.6184. PMID 10860666.{{cite journal}}: CS1 maint: overridden setting (link)
Barton JL, Herbst R, Bosisio D, Higgins L, Nicklin MJ (November 2000). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities". European Journal of Immunology. 30 (11): 3299–3308. doi:10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S. PMID 11093146.{{cite journal}}: CS1 maint: overridden setting (link)
Pan G, Risser P, Mao W, Baldwin DT, Zhong AW, Filvaroff E, et al. (January 2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp". Cytokine. 13 (1): 1–7. doi:10.1006/cyto.2000.0799. PMID 11145836.{{cite journal}}: CS1 maint: overridden setting (link)
Lin H, Ho AS, Haley-Vicente D, Zhang J, Bernal-Fussell J, Pace AM, et al. (June 2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". The Journal of Biological Chemistry. 276 (23): 20597–20602. doi:10.1074/jbc.M010095200. PMID 11278614.{{cite journal}}: CS1 maint: overridden setting (link)
Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, et al. (August 2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology. 167 (3): 1440–1446. doi:10.4049/jimmunol.167.3.1440. PMID 11466363. S2CID 85986577.{{cite journal}}: CS1 maint: overridden setting (link)
Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, et al. (October 2001). "A new nomenclature for IL-1-family genes". Trends in Immunology. 22 (10): 536–537. doi:10.1016/S1471-4906(01)02040-3. PMID 11574262.{{cite journal}}: CS1 maint: overridden setting (link)
Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics. 79 (5): 718–725. doi:10.1006/geno.2002.6751. PMID 11991722.{{cite journal}}: CS1 maint: overridden setting (link)
Garnero P, Borel O, Sornay-Rendu E, Duboeuf F, Jeffery R, Woo P, Delmas PD (July 2002). "Association between a functional interleukin-6 gene polymorphism and peak bone mineral density and postmenopausal bone loss in women: the OFELY study". Bone. 31 (1): 43–50. doi:10.1016/S8756-3282(02)00810-4. PMID 12110411.{{cite journal}}: CS1 maint: overridden setting (link)
Towne JE, Garka KE, Renshaw BR, Virca GD, Sims JE (April 2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs". The Journal of Biological Chemistry. 279 (14): 13677–13688. doi:10.1074/jbc.M400117200. PMID 14734551.{{cite journal}}: CS1 maint: overridden setting (link)
Zhan X, Desiderio DM (July 2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Analytical Biochemistry. 354 (2): 279–289. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
Blumberg H, Dinh H, Trueblood ES, Pretorius J, Kugler D, Weng N, et al. (October 2007). "Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation". The Journal of Experimental Medicine. 204 (11): 2603–2614. doi:10.1084/jem.20070157. PMC 2118475. PMID 17908936.{{cite journal}}: CS1 maint: overridden setting (link)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136694 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026984 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10625660-5] Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (January 2000). "Four new members expand the interleukin-1 superfamily". The Journal of Biological Chemistry. 275 (2): 1169–1175. doi:10.1074/jbc.275.2.1169. PMID 10625660.

[entrez-6] "Entrez Gene: IL1F6 interleukin 1 family, member 6 (epsilon)".

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References

Further reading