ING5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesING5, p28inhibitor of growth family member 5
External IDsOMIM: 608525 MGI: 1922816 HomoloGene: 90955 GeneCards: ING5
Orthologs
SpeciesHumanMouse
Entrez

84289

66262

Ensembl

ENSG00000168395

ENSMUSG00000026283

UniProt

Q8WYH8

Q9D8Y8

RefSeq (mRNA)

NM_032329
NM_001330161
NM_001330162

NM_025454
NM_029340

RefSeq (protein)

NP_001317090
NP_001317091
NP_115705

NP_079730

Location (UCSC)Chr 2: 241.69 – 241.73 MbChr 1: 93.73 – 93.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.[5][6]

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.[6]

Interactions

ING5 has been shown to interact with EP300[5] and P53.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000168395 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026283 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity". Cancer Res. 63 (10): 2373–8. PMID 12750254.
  6. 1 2 "Entrez Gene: ING5 inhibitor of growth family, member 5".

Further reading


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