ITGB1BP3

NMRK2
Identifiers
Aliases	NMRK2, ITGB1BP3, MIBP, NRK2, nicotinamide riboside kinase 2
External IDs	OMIM: 608705 MGI: 1916814 HomoloGene: 113783 GeneCards: NMRK2
EC number	2.7.1.173
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,942,416 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,037,885 bp
RNA expression pattern
	Top expressed in
	left ventricle; ; gastrocnemius muscle; ; triceps brachii muscle; ; right ventricle; ; vastus lateralis muscle; ; biceps brachii; ; thoracic diaphragm; ; body of tongue; ; tibialis anterior muscle; ; deltoid muscle;
	Top expressed in
	knee joint; ; vastus lateralis muscle; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; digastric muscle; ; skeletal muscle tissue; ; tibialis anterior muscle; ; temporal muscle; ; soleus muscle; ; intercostal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein binding; ATP binding; metal ion binding; kinase activity; ribosylnicotinamide kinase activity; ribosylnicotinate kinase activity;
Cellular component	intracellular anatomical structure; nucleoplasm; cytosol; plasma membrane; intracellular membrane-bounded organelle;
Biological process	pyridine nucleotide biosynthetic process; negative regulation of myoblast differentiation; NAD biosynthetic process; phosphorylation; NAD metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	27231
	69564
	ENSG00000077009
	ENSMUSG00000004939
	Q9NPI5
	Q9D7C9
NM_001289117; NM_014446; NM_170678; NM_001375467; NM_001375468;
	NM_001375469
	NM_027120
	NP_001276046; NP_733778; NP_001362396; NP_001362397; NP_001362398
	NP_081396
	Wikidata
View/Edit Human	View/Edit Mouse

Nicotinamide riboside kinase 2 is an enzyme that in humans is encoded by the ITGB1BP3 gene.^[5]^[6]^[7]

Interactions

ITGB1BP3 has been shown to interact with ST7.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000077009 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004939 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Li J, Mayne R, Wu C (Feb 2000). "A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation". J Cell Biol. 147 (7): 1391–8. doi:10.1083/jcb.147.7.1391. PMC 2174245. PMID 10613898.
↑ Bieganowski P, Brenner C (May 2004). "Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans". Cell. 117 (4): 495–502. doi:10.1016/S0092-8674(04)00416-7. PMID 15137942. S2CID 4642295.
↑ "Entrez Gene: ITGB1BP3 integrin beta 1 binding protein 3".
↑ Battle, Michele A; Maher Veronica M; McCormick J Justin (Jun 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry. United States. 42 (24): 7270–82. doi:10.1021/bi034081y. ISSN 0006-2960. PMID 12809483.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Li J, Rao H, Burkin D, et al. (2003). "The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition". Dev. Biol. 261 (1): 209–19. doi:10.1016/S0012-1606(03)00304-X. PMID 12941630.
Battle MA, Maher VM, McCormick JJ (2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry. 42 (24): 7270–82. doi:10.1021/bi034081y. PMID 12809483.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000077009 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004939 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10613898-5] Li J, Mayne R, Wu C (Feb 2000). "A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation". J Cell Biol. 147 (7): 1391–8. doi:10.1083/jcb.147.7.1391. PMC 2174245. PMID 10613898.

[pmid15137942-6] Bieganowski P, Brenner C (May 2004). "Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans". Cell. 117 (4): 495–502. doi:10.1016/S0092-8674(04)00416-7. PMID 15137942. S2CID 4642295.

[entrez-7] "Entrez Gene: ITGB1BP3 integrin beta 1 binding protein 3".

[pmid12809483-8] Battle, Michele A; Maher Veronica M; McCormick J Justin (Jun 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry. United States. 42 (24): 7270–82. doi:10.1021/bi034081y. ISSN 0006-2960. PMID 12809483.

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Interactions

References

Further reading