Infracyanine green (IFCG) is a cyanine dye used in medical diagnostics especially in ophthalmology. Unlike Indocyanine green (ICG) it is an iodine free dye.[1]

Properties

Pharmacological properties of infracyanine green are similar to ICG.[2] Since IFCG is iodine free, instead of ICG, it is used in patients with iodine allergy. Though it is impossible to be allergic to iodine as this would be incompatible with human life.[3] It has a peak spectral absorption between 600 nm to 700 nm.[4] IFCG can be dissolved in 5% glucose solution instead of pure water, which makes it less cytotoxic in rabbits macular applications.[5]

Uses

Infracyanine green which stains the Internal limiting membrane layer of retina,[6] is used to see structures to be removed during vitreoretinal surgery.[7]

Toxicity

At a concentration above 0.05% IFCG may induce acute and chronic toxicities.[7] But the retinal phototoxicity caused by IFCG is lesser compared to Indocyanine green in one study in cell cultures.[4]

References

  1. ↑ Jackson, Timothy L.; Vote, Brendan; Knight, Bruce C.; El-Amir, Ahmed; Stanford, Miles R.; Marshall, John (1 October 2004). "Safety Testing of Infracyanine Green Using Retinal Pigment Epithelium and Glial Cell Cultures". Investigative Ophthalmology & Visual Science. 45 (10): 3697–4303. doi:10.1167/iovs.04-0387. PMID 15452079.
  2. ↑ Saxena, Sandeep; Meyer, Carsten H.; Ohji, Masahito; Akduman, Levent (2011-10-25). Vitreoretinal Surgery. JP Medical Ltd. ISBN 978-93-5025-579-7.
  3. ↑ Dithmar, S. (2008). Fluorescence angiography in ophthalmology. Frank G. Holz. Heidelberg: Springer Medizin Verlag. p. 3. ISBN 978-3-540-79401-1. OCLC 288578300.
  4. 1 2 Jackson, Timothy; Vote, Brendan; Knight, Bruce; El-Amir, Ahmed; Stanford, Miles; Marshall, John (2004-11-01). "Safety Testing of Infracyanine Green Using Retinal Pigment Epithelium and Glial Cell Cultures". Investigative Ophthalmology & Visual Science. 45 (10): 3697–703. doi:10.1167/iovs.04-0387. PMID 15452079.
  5. ↑ Alander, Jarmo T.; Kaartinen, Ilkka; Laakso, Aki; Pätilä, Tommi; Spillmann, Thomas; Tuchin, Valery V.; Venermo, Maarit; Välisuo, Petri (2012-04-22). "A Review of Indocyanine Green Fluorescent Imaging in Surgery". International Journal of Biomedical Imaging. 2012: e940585. doi:10.1155/2012/940585. ISSN 1687-4188. PMC 3346977. PMID 22577366.
  6. ↑ "Chromovitrectomy - EyeWiki". eyewiki.aao.org. Retrieved 2022-04-10.
  7. 1 2 Kodjikian, L.; Richter, T.; Halberstadt, M.; Beby, F.; Flueckiger, F.; Boehnke, M.; Garweg, J. G. (September 2005). "Toxic effects of indocyanine green, infracyanine green, and trypan blue on the human retinal pigmented epithelium". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie. 243 (9): 917–925. doi:10.1007/s00417-004-1121-6. ISSN 0721-832X. PMID 15834606. S2CID 35819267.


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