Interventional oncology (abbreviated IO) is a subspecialty field of interventional radiology that deals with the diagnosis and treatment of cancer and cancer-related problems using targeted minimally invasive procedures performed under image guidance.[1][2] Interventional oncology has developed to a separate pillar of modern oncology and it employs X-ray, ultrasound, computed tomography (CT) or magnetic resonance imaging (MRI) to help guide miniaturized instruments (e.g. biopsy needles, ablation electrodes, intravascular catheters) to allow targeted and precise treatment of solid tumours (also known as neoplasms) located in various organs of the human body, including but not limited to the liver, kidneys, lungs, and bones.[3][4] Interventional oncology treatments are routinely carried out by interventional radiologists in appropriate settings and facilities.[5]

Procedures performed

Interventional oncology procedures are generally divided between diagnostic procedures that help obtain tissue diagnosis of suspicious neoplasms and therapeutic ones that aim to cure or palliate the tumour. Therapeutic interventional oncology procedures may be classified further into ablation techniques that destroy neoplastic tissues by delivery of some form of heat, cryo or electromagnetic energy and embolization techniques that aim to occlude the blood vessels feeding the tumour and thereby destroy it by means of ischemia. Both ablation and embolization techniques are minimally invasive treatment, i.e. they may be delivered through the skin (in a percutaneous way) without the need for any skin incisions or other form of open surgery. Hence, most treatments are nowadays offered as day case or outpatient appointments and patients may enjoy rapid recovery and minimal pain and discomfort with low rates of complications.[6]

Diagnostic techniques

  • Fine-needle aspiration: biopsy with a fine needle trying to obtain tissue diagnosis by examining the tumour cells.
  • Core needle biopsy: similar to fine-needle aspiration, only involving the use of larger needles to excise the tissue.
  • Vacuum-assisted biopsy: similar to core needle aspiration but using vacuum assistance to gather the sample. Vacuum assisted breast biopsy may provide a high diagnostic yield in case of breast tumours.

Image-guided ablation

Uses different types of energy to burn (radiofrequency ablation (RFA) and microwave ablation (MWA)), deliver electrical fields/electroporate (irreversible electroporation(IRE)) or freeze (cryoablation) solid tumors resulting in tumor cell death. Ablation techniques can be performed throughout the body such as in the lung,[7] liver,[8][9] kidney,[10] prostate,[11] breast,[12] bone,[13] and other organs using image guidance to place a needle/probe through the skin into the target tissue.

High-intensity focused ultrasound (HIFU)

Uses a machine that emits high frequency sound waves to kill cancer cells and provide relief for tumor-related pain, such as in the bone.

Embolisation techniques

  • Transarterial embolization (TAE)/bland embolization: Injection of embolic material (microparticles, alcohol, glue) through a catheter into the arteries feeding a tumor in order to completely occlude the tumor's blood supply and cause cell death. The most common indication is for treatment of unresectable liver cancer (hepatocellular carcinoma).[16]
  • Trans(catheter) arterial chemoembolization (TACE): Injection of a chemotherapy agent often with microparticles through a catheter into arteries feeding a tumor that both delivers chemotherapy and blocks the blood supply to the tumor to cause cell death[17]
    • Can be performed in different ways:
      • Conventional transarterial chemoembolization (cTACE): Injection of lipiodol with high dose chemotherapy with or without microparticles directly into the tumor-feeding arteries.[18]
      • Drug-eluting bead chemoembolization (DEB-TACE): delivery of microparticles that are themselves loaded with the chemotherapy agent – typically doxorubicin or irinotecan.[17]
  • Selective internal radiation therapy (also known as SIRT or Y-90 radioembolization): Injection of small beads loaded with a radioactive isotope, Yittrium-90 (Y-90), into blood vessels feeding a tumor in order to deliver a lethal dose of radiation causing cell death.[19] Can be performed in a segmental (radiation segmentectomy) or a lobar (Radiation Lobectomy) fashion. Radiation lobectomy is commonly performed with the goal of inducing growth of the non-diseased lobe in order to have adequate liver function necessary to undergo surgical resection.
  • Intra-arterial chemotherapy: high dose chemotherapy is administered directly into the tumor-feeding arteries.[20]
  • Portal vein embolization (PVE): delivery of embolic material into the portal vein feeding the lobe of liver containing the tumor(s) of interest to induce growth of the non-diseased lobe in order to have adequate liver function necessary to undergo surgical resection of lobe containing the tumor(s).[21]

Palliative techniques

Interventional oncology has long been used to provide palliative care for patients. IO procedures can help reduce cancer-related pain and improve patients’ quality of life. Tumours can intrude into various ducts and blood vessels of the body, obstructing the vital passage of food, blood or waste. The interventional radiological treatment known as stenting can be used to re-open blockages, for example of the esophagus or bile ducts in cases of esophageal cancer or cholangiocarcinoma, respectively, considerably relieving the patient's adverse symptoms.[22]

Diseases treated

Interventional oncology (IO) procedures are commonly applied to treat primary or metastatic cancer. IO treatments may be also offered in combination with any of the above oncological therapies in order to augment the therapeutic outcome in more complex or widespread (metastatic) cancer cases. There is a variety of applications of interventional oncological treatments for tumors that arise in the:

  • Lung: lung metastases or inoperable primary lung cancer can be treated by interventional radiology procedures such as image guided ablation (cryoablation, microwave ablation and radiofrequency ablation).[24]
  • Kidney: kidney tumors such as renal cell carcinoma can be treated with image guided ablation (RFA, MWA, cryotherapy) with similar results to partial nephrectomy.[25] Benign kidney tumors such as angiomyolipomas can be treated with transarterial embolization to shrink the tumor size and reduce the risk of rupture/bleeding. Other embolizations are also performed for symptom relief or prior to surgery to reduce bleeding.[26]
  • Bone (or as metastases): bone metastases located in the spine, pelvis and long bones can be treated with image guided ablative techniques (RFA, MWA, cryoablation, electroportation) with or without injection of cement (cementoplasty) to stabilize the bone. These treatments may be palliatively for bone metastases pain or for some cases such as osteoid osteoma can curatively treat tumors. Embolizations are also performed for prior to surgery to reduce bleeding.[27]
  • Breast: for small, solitary breast cancer image guided ablative techniques are used to treat tumors, however their efficacy versus surgical resection has not yet been studied.[28]

Milestones

  • 1930 – First therapeutic embolization procedure (of a carotid-cavernous fistula); described by Brooks.[30]
  • 1960s – Radioisotopes such as Yttrium-90 (Y90) started to be investigated for the use in cancer treatments.
  • 1966 – Embolization therapy to treat tumors and spinal cord vascular malformations by blocking the blood flow.
  • 1969 – The catheter-delivered stenting technique and prototype stent.
  • 1970s – Embolisation agents started to be used in palliative care to treat liver tumors.
  • 1980 – Cryoablation to freeze liver tumors.
  • 1983 – Laser interstitial thermal therapy first performed on a tumour by Bown.[31]
  • 1985 – Self-expanding stents are developed for vascular and oncological applications.
  • 1990 – Radiofrequency ablation (RFA) technique for liver tumors.
  • 1990s – Treatment of bone and kidney tumors by embolization.
  • 1990s – RFA for soft tissue tumors, i.e., bone, breast, kidney, lung and liver cancer.
  • 1997 – Intra-arterial delivery of tumor-killing viruses and gene therapy vectors to the liver.
  • 1997 – HIFU first used to treat prostate cancer.
  • 2012 – Pioneering liver chemoperfusion study reported by Delcath for disseminated liver metastases.[32]

Benefits

While the surgical resection of tumours is generally accepted to offer the best long-term solution, it is often not possible due to the size, number or location of the tumour. IR therapies may be applied to shrink the tumour, making a surgical or interventional treatment possible. Some patient groups may also be too weak to undergo open surgery. IR treatments can be applied in these complex cases to provide effective and milder forms of treatment. Interventional oncological techniques can also be used in combination with other treatments to help increase their efficacy. For example, IO techniques can be used to shrink large tumours making them easier to excise. Chemotherapeutic drugs can also be administered intra-arterially, increasing their potency and removing the harsh effects of system-wide application.

Patients can greatly benefit from IO treatments. The minimally invasive nature of the treatments means they cause less pain, fewer side effects and shorter recovery times. Many IO procedures can be performed on an outpatient basis, freeing up hospital beds and reducing costs.[33]

Further considerations

Multidisciplinary approach

Cancer is a multifaceted disease group that requires a multidisciplinary approach to treatment. Numerous studies have shown that cancer patients treated in multidisciplinary environments benefit greatly from the combined expertise. Interventional Radiologists are seen as playing a major role in multidisciplinary cancer teams where they provide innovative solutions to improve combined therapies and to treat complications.[34]

Patient selection

Proper patient selection is the key element for the success of any medical procedure and improper conduct can have fatal consequences. Patient selection protocols must be strictly followed before treating patients with IO procedures.

Radiation protection

IO treatments are carried out under image guidance. For this reason practitioners must have attained solid training in radiation protection.

See also

References

  1. ↑ Hickey, Ryan; Vouche, Michael; Sze, Daniel Y.; Hohlastos, Elias; Collins, Jeremy; Schirmang, Todd; Memon, Khairuddin; Ryu, Robert K.; Sato, Kent; Chen, Richard; Gupta, Ramona; Resnick, Scott; Carr, James; Chrisman, Howard B.; Nemcek, Albert A.; Vogelzang, Robert L.; Lewandowski, Robert J.; Salem, Riad (2013). "Cancer Concepts and Principles: Primer for the Interventional Oncologist—Part II". Journal of Vascular and Interventional Radiology. 24 (8): 1167–1188. doi:10.1016/j.jvir.2013.04.023. PMC 3800031. PMID 23810312.
  2. ↑ Hickey, Ryan; Vouche, Michael; Sze, Daniel Y.; Hohlastos, Elias; Collins, Jeremy; Schirmang, Todd; Memon, Khairuddin; Ryu, Robert K.; Sato, Kent; Chen, Richard; Gupta, Ramona; Resnick, Scott; Carr, James; Chrisman, Howard B.; Nemcek, Albert A.; Vogelzang, Robert L.; Lewandowski, Robert J.; Salem, Riad (2013). "Cancer Concepts and Principles: Primer for the Interventional Oncologist—Part I". Journal of Vascular and Interventional Radiology. 24 (8): 1157–1164. doi:10.1016/j.jvir.2013.04.024. PMC 3800037. PMID 23809510.
  3. ↑ "Interventional Radiology Treatments for Liver Cancer". Archived from the original on 2016-12-04. Retrieved 2015-05-07.
  4. ↑ Pereira, Philippe L.; Salvatore, Masala; Cardiovascular Interventional Radiological Society of Europe (CIRSE) (2012). "Standards of Practice: Guidelines for Thermal Ablation of Primary and Secondary Lung Tumors". CardioVascular and Interventional Radiology. 35 (2): 247–254. doi:10.1007/s00270-012-0340-1. PMID 22271076. S2CID 20280474.
  5. ↑ The Royal College of Radiologists UK. Interventional Oncology: Guidance for Service delivery
  6. ↑ Cardiovascular and Interventional Radiological Society of Europe, "IR Procedures"
  7. ↑ "Radiofrequency ablation for lung cancer". nhs.uk. 2017-08-21. Retrieved 2019-10-29.
  8. ↑ Radiology (ACR), Radiological Society of North America (RSNA) and American College of. "Radiofrequency Ablation (RFA) | Microwave Ablation (MWA) - Liver Tumors". www.radiologyinfo.org. Retrieved 2019-10-29.
  9. ↑ "Phase 3 Study of ThermoDox With Radiofrequency Ablation (RFA) in Treatment of Hepatocellular Carcinoma (HCC) - Full Text View - ClinicalTrials.gov". clinicaltrials.gov. 24 March 2017. Retrieved 2019-10-29.
  10. ↑ El Dib, Regina; Touma, Naji J.; Kapoor, Anil (August 2012). "Cryoablation vs radiofrequency ablation for the treatment of renal cell carcinoma: a meta-analysis of case series studies". BJU International. 110 (4): 510–516. doi:10.1111/j.1464-410X.2011.10885.x. ISSN 1464-410X. PMID 22304329. S2CID 36726814.
  11. ↑ "Cryotherapy for Prostate Cancer". www.cancer.org. Retrieved 2019-10-29.
  12. ↑ Sabel, Michael S. (July 2014). "Nonsurgical ablation of breast cancer: future options for small breast tumors". Surgical Oncology Clinics of North America. 23 (3): 593–608. doi:10.1016/j.soc.2014.03.009. ISSN 1558-5042. PMID 24882353.
  13. ↑ Santiago, Fernando Ruiz; del Mar Castellano García, María; Montes, Jose Luis Martínez; García, Manuel Ruiz; Fernández, Juan Miguel Tristán (2009-01-07). "Treatment of bone tumours by radiofrequency thermal ablation". Current Reviews in Musculoskeletal Medicine. 2 (1): 43–50. doi:10.1007/s12178-008-9042-3. ISSN 1935-973X. PMC 2684952. PMID 19468917.
  14. ↑ Napoli, Alessandro; Anzidei, Michele; Marincola, Beatrice Cavallo; Brachetti, Giulia; Noce, Vincenzo; Boni, Fabrizio; Bertaccini, Luca; Passariello, Roberto; Catalano, Carlo (2013). "MR Imaging–guided Focused Ultrasound for Treatment of Bone Metastasis". Radiographics. 33 (6): 1555–1568. doi:10.1148/rg.336125162. PMID 24108551.
  15. ↑ Gangi, A.; Basile, A.; Buy, X.; Alizadeh, H.; Sauer, B.; Bierry, G. (2005). "Radiofrequency and laser ablation of spinal lesions". Seminars in Ultrasound, CT and MRI. 26 (2): 89–97. doi:10.1053/j.sult.2005.02.005. PMID 15856810.
  16. ↑ Shah, Rajesh P.; Brown, Karen T.; Sofocleous, Constantinos T. (October 2011). "Arterially directed therapies for hepatocellular carcinoma". American Journal of Roentgenology. 197 (4): W590–602. doi:10.2214/AJR.11.7554. ISSN 1546-3141. PMID 21940531.
  17. 1 2 Salem, Riad; Lewandowski, Robert J. (June 2013). "Chemoembolization and radioembolization for hepatocellular carcinoma". Clinical Gastroenterology and Hepatology. 11 (6): 604–611. doi:10.1016/j.cgh.2012.12.039. ISSN 1542-7714. PMC 3800021. PMID 23357493.
  18. ↑ "Chemotherapy Delivery Options: Benefits of Regional Therapies". Cancer Treatment Centers of America. 2018-10-17. Retrieved 2019-10-29.
  19. ↑ Al-Adra, D. P.; Gill, R. S.; Axford, S. J.; Shi, X.; Kneteman, N.; Liau, S.-S. (January 2015). "Treatment of unresectable intrahepatic cholangiocarcinoma with yttrium-90 radioembolization: a systematic review and pooled analysis". European Journal of Surgical Oncology. 41 (1): 120–127. doi:10.1016/j.ejso.2014.09.007. ISSN 1532-2157. PMC 4316196. PMID 25449754.
  20. ↑ Cancer Treatment Center of America, Intra-Arterial chemotherapy
  21. ↑ May, Benjamin J.; Madoff, David C. (June 2012). "Portal vein embolization: rationale, technique, and current application". Seminars in Interventional Radiology. 29 (2): 81–89. doi:10.1055/s-0032-1312568. ISSN 0739-9529. PMC 3444878. PMID 23729977.
  22. ↑ Katsanos, K.; Ahmad, F.; Dourado, R.; Sabharwal, T.; Adam, A. (2009). "Interventional radiology in the elderly". Clinical Interventions in Aging. 4: 1–15. PMC 2685220. PMID 19503761.
  23. ↑ "Liver Cancer Interventional Radiology: Minimally Invasive". Cancer Treatment Centers of America. 2018-10-05. Retrieved 2019-10-29.
  24. ↑ Pereira, Philippe L.; Salvatore, Masala (April 2012). "Standards of Practice: Guidelines for Thermal Ablation of Primary and Secondary Lung Tumors". CardioVascular and Interventional Radiology. 35 (2): 247–254. doi:10.1007/s00270-012-0340-1. ISSN 1432-086X. PMID 22271076.
  25. ↑ Rivero, J. Ricardo; De La Cerda, Jose; Wang, Hanzhang; Liss, Michael A.; Farrell, Ann M.; Rodriguez, Ronald; Suri, Rajeev; Kaushik, Dharam (January 2018). "Partial Nephrectomy versus Thermal Ablation for Clinical Stage T1 Renal Masses: Systematic Review and Meta-Analysis of More than 3,900 Patients". Journal of Vascular and Interventional Radiology. 29 (1): 18–29. doi:10.1016/j.jvir.2017.08.013. ISSN 1535-7732. PMID 29102464.
  26. ↑ Foster, Ryan C.B.; Stavas, Joseph M. (June 2014). "Bone and Soft Tissue Ablation". Seminars in Interventional Radiology. 31 (2): 167–179. doi:10.1055/s-0034-1373791. ISSN 0739-9529. PMC 4078106. PMID 25053865.
  27. ↑ Kurup, Anil Nicholas; Callstrom, Matthew R. (2013-12-01). "Ablation of Musculoskeletal Metastases: Pain Palliation, Fracture Risk Reduction, and Oligometastatic Disease". Techniques in Vascular & Interventional Radiology. 16 (4): 253–261. doi:10.1053/j.tvir.2013.08.007. ISSN 1089-2516. PMID 24238380.
  28. ↑ Nguyen, Tiffany; Hattery, Eleanor; Khatri, Vijay P. (May 2014). "Radiofrequency ablation and breast cancer: a review". Gland Surgery. 3 (2): 128–135. doi:10.3978/j.issn.2227-684X.2014.03.05. ISSN 2227-684X. PMC 4115759. PMID 25083506.
  29. ↑ Martin, Robert C. G. (June 2015). "Use of irreversible electroporation in unresectable pancreatic cancer". Hepatobiliary Surgery and Nutrition. 4 (3): 211–215. doi:10.3978/j.issn.2304-3881.2015.01.10. ISSN 2304-3881. PMC 4465607. PMID 26151062.
  30. ↑ Barney Brooks, The Treatment of Traumatic Arteriovenous Fistula, Southern Medical Journal. 01/1930; 23(2):100-106.
  31. ↑ Bown SG (1983). "Phototherapy in tumors". World Journal of Surgery. 7 (6): 700–709. doi:10.1007/BF01655209. PMID 6419477. S2CID 2574459.
  32. ↑ Deneve, Jeremiah L.; Choi, Junsung; et al. (December 2012). "Chemosaturation with Percutaneous Hepatic Perfusion for Unresectable Isolated Hepatic Metastases from Sarcoma". CardioVascular and Interventional Radiology. 35 (6): 1480–1487. doi:10.1007/s00270-012-0425-x. PMID 22699779. S2CID 25073546.
  33. ↑ "What is IO?". European Conference of Interventional Oncology. Cardiovascular and Interventional Radiological Society of Europe. Archived from the original on 2015-03-13.
  34. ↑ Adam, Andreas; Kenny, Lizbeth M. (2015). "Interventional oncology in multidisciplinary cancer treatment in the 21st century". Nature Reviews Clinical Oncology. 12 (2): 105–113. doi:10.1038/nrclinonc.2014.211. PMID 25445561. S2CID 7689364.
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