Ivan Đikić
Born (1966-05-28) 28 May 1966
Zagreb, Croatia
Alma materUniversity of Zagreb
New York University
Known forOncogenic signaling, ubiquitin signaling
AwardsGottfried Wilhelm Leibniz Prize (2013)
William C. Rose Award (2013)
Ernst Jung Prize (2013)
German Cancer Prize (2010)
AACR Award (2006)
Louis-Jeantet Prize (2023)
Scientific career
FieldsCancer research, Cell biology, Signal transduction, Autophagy, Ubiquitin
InstitutionsGoethe University Frankfurt, University of Split
ThesisThe Role of RAS Messenger in Supervision of Division and Cell Differentiation (1997)
Doctoral advisorKrešimir Pavelić

Ivan Đikić (born 28 May 1966[1]) is a Croatian-German molecular biologist who is the Director of the Institute of Biochemistry II at Goethe University Frankfurt.

Scientific career

In 1991, he earned his MD degree from the Faculty of Medicine at the University of Zagreb.[2] After finishing his medical studies, he continued to pursue his PhD thesis in molecular biology at the University of Zagreb and at the New York University School of Medicine until 1997. He continued to work as a postdoctoral fellow in the laboratory of Joseph Schlessinger in New York from 1995 to 1997 before starting his own group at the Ludwig Institute for Cancer Research in Uppsala (Sweden).[2]

In 2002, Đikić was appointed as a Professor at Goethe University Frankfurt. He followed in Werner Müller-Esterl's footsteps as Director of the Institute of Biochemistry II in 2009. In addition, Đikić was the first Scientific Director (2009–2013) of the Buchmann Institute for Molecular Life Sciences, a cross-faculty, interdisciplinary institute at Goethe University which was founded as part of the Cluster of Excellence Macromolecular Complexes. He is speaker of the Collaborative Research Center 1177 on selective autophagy, and speaker of the LOEWE program "Ubiquitin Networks".

Đikić has an affiliation as Professor with the School of Medicine University of Split, where he established an outstation lab in Split University and transferring technologies to Croatia. In addition, Đikić has been recognized by one of the highest civilian honours, The Order of Duke Branimir, bestowed by the President of Croatia.[3]

Đikić is member of several academic societies, including the number of organizations including the European Molecular Biology Organization (since 2004), the World Academy of Art and Science (since 2008), German National Academy of Sciences Leopoldina (since 2010),[2] the American Academy of Arts and Sciences (since 2019),[4] the Croatian Academy of Medical Science, and the European Academy of Sciences.

He is a member of the editorial board for Cell.[5]

Research

Đikić's research focuses on deciphering molecular mechanisms of cellular signaling pathways, which have a high relevance to human diseases such as cancer, neurodegenerative disorders and inflammation. Early on, he started to focus on ubiquitin to understand how this modification controls multiple cellular functions, and managed to prove a concept of ubiquitin signal recognition by specialized domains serving as specific receptors.[6] More recently, his team has revealed the functions of linear ubiquitin chains in pathogen defense and overall immune response. He expanded his research to the field of selective autophagy, recognizing the enormous impact of the LC3/GABARAP signaling network displaying striking mechanistic similarities to ubiquitin. One major focus is on the crosstalk between autophagy and endocytic machineries, and in this context he has gained fundamental insight in autophagic processes at the endoplasmic reticulum (ER-phagy).

Education

In 1998, Đikić initiated the series of Dubrovnik Cell Signalling Conferences, which has been sponsored by EMBO continuously since 2004. Moreover, he is actively involved in organization of EMBO Meetings (Ubiquitin Meetings in 2015, 2013; Autophagy Meeting 2011, Cellular Microbiology/Cell Biology Meeting in 2010, 2008), EMBO Courses (2012, 2010, 2008, 2006 on Ubiquitin/SUMO; 2010 on Ubiquitin & DNA damage) as well as Keystone and CSH Meetings. In July 2016, he was hosting the Frankfurt Conference on Ubiquitin and Autophagy together with Volker Dötsch, Hubert Serve and Heide Genau.

Personal life

He's married to Inga Đikić with whom he has three children.[7] He's a Christian of Roman Catholic denomination and has stated publicly that he sees no conflict between science and religion.[8]

Honors and awards

References

  1. 1 2 3 4 5 6 7 8 9 "CV" (PDF).
  2. 1 2 3 "Ivan Đikić". vecernji.hr (in Croatian). Archived from the original on 2 February 2017. Retrieved 5 March 2017.
  3. 1 2 "Ivan Dikic". Max Planck Institute of Biophysics. 28 September 2021. Retrieved 27 November 2021.
  4. ↑ "Ivan Dikic elected to the American Academy of Arts and Sciences – Aktuelles aus der Goethe-Universität Frankfurt". 24 April 2019.
  5. ↑ "Editorial Board: Cell". www.cell.com.
  6. ↑ "New chemistry of life: Novel ubiquitination mechanism explains pathogenic effects of Legionella infection". Phys.org. 1 December 2016. Retrieved 13 March 2017.
  7. ↑ "Enciklopedija Večernjeg list: Ivan Đikić". Večernji list. Vecernji list (in Croatian). Retrieved 8 December 2017.
  8. ↑ "Ivan Đikić samo za Slobodnu: Da, ja sam znanstvenik i vjernik. Jedno ne isključuje drugo". Slobodna Dalmacija (in Croatian). Slobodna Dalmacija. 3 April 2016. Retrieved 8 December 2017.
  9. ↑ "Ivan Dikic receives Award from GlaxoSmithKline Foundation". Croatian World Network. 5 April 2006. Retrieved 27 November 2021.
  10. 1 2 3 "Ivan Dikic, MD, PhD". The Vallee Foundation. 1 January 2020. Retrieved 27 November 2021.
  11. ↑ "Ivan Dikic awarded ERC Advanced Investigator Grant". BMLS. 11 April 2017. Retrieved 27 November 2021.
  12. ↑ "Ivan Đikić: Hrvatska znanstvena zvijezda u prestižnoj njemačkoj akademiji". Nacional (in Croatian). No. 777. 5 October 2010. Retrieved 6 March 2017.
  13. ↑ "Professor Ivan Dikic receives Ernst Jung Prize for medicine". idw-online.de. Informationsdienst Wissenschaft. 1 August 2013. Retrieved 6 March 2017.
  14. 1 2 "Ivan Dikic". Institute of Biochemistry II │ Goethe University Medical Faculty, Frankfurt. Retrieved 27 November 2021.
  15. ↑ "Liste der Leibniz-Preisträger 1986 – 2017" [List of all prize recipients 1986–2015] (PDF) (in German). Deutsche Forschungsgemeinschaft. 2017. Retrieved 15 March 2017.
  16. ↑ "25 Aug 2014 – Ivan Dikic to become a Vallee Visiting Professor at Harvard Medical School". Institute of Biochemistry II │ Goethe University Medical Faculty, Frankfurt. 25 August 2014. Retrieved 27 November 2021.
  17. ↑ "Academy of Europe: Dikic Ivan". www.ae-info.org. Retrieved 4 September 2020.
  18. ↑ "Ivan Đikić". American Academy of Arts & Sciences. Retrieved 4 September 2020.
  19. ↑ "Louis-Jeantet Prize 2023".
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