AJUBA
Identifiers
AliasesAJUBA, JUB, ajuba LIM protein
External IDsOMIM: 609066 MGI: 1341886 HomoloGene: 7789 GeneCards: AJUBA
Orthologs
SpeciesHumanMouse
Entrez

84962

16475

Ensembl

ENSG00000129474

ENSMUSG00000022178

UniProt

Q96IF1

Q91XC0

RefSeq (mRNA)

NM_198086
NM_001289097
NM_032876

NM_010590

RefSeq (protein)

NP_001276026
NP_116265
NP_932352

NP_034720

Location (UCSC)Chr 14: 22.97 – 22.98 MbChr 14: 54.8 – 54.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein ajuba is a protein that in humans is encoded by the JUB gene.[5][6]

Function

JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment.

Interactions

JUB (gene) has been shown to interact with Stratifin[7] and SLC1A2.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000129474 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022178 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD (Jun 1999). "Ajuba, a Novel LIM Protein, Interacts with Grb2, Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of Xenopus Oocytes in a Grb2- and Ras-Dependent Manner". Mol Cell Biol. 19 (6): 4379–89. doi:10.1128/MCB.19.6.4379. PMC 104397. PMID 10330178.
  6. "Entrez Gene: JUB jub, ajuba homolog (Xenopus laevis)".
  7. Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  8. Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D (Feb 2002). "The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba". Mol. Cell. Neurosci. 19 (2): 152–64. doi:10.1006/mcne.2001.1066. PMID 11860269. S2CID 45768895.

Further reading


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