1990s

Mercurio's writing debut, Cardiac Arrest (1994–96), caused controversy due to its realistic depiction of hospital life.^[18][19] The series was twice nominated in the Best Original Drama category by the Writers' Guild of Great Britain^[20] and topped a poll of UK medical professionals as the most realistic medical drama of all time.^[21] Mercurio served as medical adviser on the second series of Cardiac Arrest, which he cites as his apprenticeship in producing/directing.^[13]

Mercurio wrote and produced the science fiction drama series Invasion: Earth which ran for six episodes on BBC1 in 1998.^[22][23]

Jed Mercurio entered a new genre when he created The Grimleys, a comedy series set in the Black Country, which ran for three series (1999–2001) on ITV.^[24]

2000s

Mercurio adapted his first novel, Bodies (2002),^[25] into an award-winning television series.^[26] Mercurio assumed the producer/showrunner position for the first time on Bodies (2004–06), a role he has fulfilled on all his subsequent original series.^[13] The Times ranked Bodies in "Shows of the Decade" and The Guardian placed it in "The Greatest TV Dramas of All Time."^[27] The series won the Royal Television Society Award for Best Drama Series, was twice nominated for the BAFTA Award for Best Drama Series and Mercurio was also twice nominated as Best Drama Writer by the Royal Television Society.^[28]

His critically acclaimed second novel, Ascent (2007),^[29] was ranked among the 1000 Novels Everyone Must Read.^[30]

2010s

Mercurio's next original drama series, Line of Duty (first broadcast 26 June 2012), premiered as BBC2's then best-performing drama series in 10 years with 4.1 million viewers.^[31] A well-received second series (first broadcast 12 February 2014) resulted in the BBC commissioning two further series for production in 2015 and 2016.^[32] The first series was nominated for a Royal Television Society Award for Best Drama Series and earned Mercurio his third nomination as Best Drama Writer by the Royal Television Society and The Writers' Guild of Great Britain.^[33] In 2014, Line of Duty was named in the Top 50 BBC2 Shows of All-Time,^[34] and named best television drama of the year by The Observer,^[35] and in 2016 ranked among the best BBC shows of all time^[36] and among the best police series of all time.^[37] In 2015, the second series won the Royal Television Society Award for Best Drama Series.^[38] and was nominated for four BAFTA Awards.^[39][40] Series 3 of Line of Duty became the most watched drama series broadcast on BBC2 in the multichannel era.^[41] Series 4 transferred to BBC One, consisting of six episodes broadcast from 26 March 2017.^[42]

Mercurio's third medical drama series, Critical, ran for 13 episodes on Sky1 from 24 February 2015 to predominantly positive reviews,^{[43][44][45][46]} but was cancelled on 15 July 2015 after one season.^[47]

Mercurio created and wrote Bodyguard, serving as showrunner on the six-part series starring Richard Madden and Keeley Hawes.^[48] The series began broadcasting on BBC One on 26 August 2018,^[49] achieving the highest viewing figures for a new BBC drama in the multichannel era.^[50]

2020s

In 2021 Mercurio and Jimmy Mulville, via HTM Television, inked a first-look deal with 20th Television in an effort to expand into the US.^[51]

In 2023, HTM created the six-part drama Payback, starring Morven Christie opposite Peter Mullan, which aired on ITV and internationally.^[52] The series is written by Debbie O'Malley, and Mercurio and Mulville are credited as executive producers, along with several others.^[53]