John R. Yates
Alma materUniversity of Maine
University of Virginia
Known forMass Spectrometry
AwardsRalph N. Adams Award in Bioanalytical Chemistry (2015)
ACS Award in Analytical Chemistry (2015)
Scientific career
FieldsChemist
InstitutionsThe Scripps Research Institute

John R. Yates III is an American chemist and Ernest W. Hahn Professor in the Departments of Molecular Medicine and Neurobiology at The Scripps Research Institute in La Jolla, California.

His work is focused on developing tools and in proteomics and he specializes in mass spectrometry. He is best known for the development of the SEQUEST algorithm for automated peptide sequencing[1] and Multidimensional Protein Identification Technology (MudPIT)[2] and data independent analysis (DIA).[3] His laboratory has made important contributions to understanding the biochemical mechanisms behind the failure of DF508 cystic fibrosis ion transport regulator (CFTR) to mature.[4][5]

References

  1. ↑ Eng, Jimmy K.; McCormack, Ashley L.; Yates, John R. (November 1994). "An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database". Journal of the American Society for Mass Spectrometry. 5 (11): 976–989. doi:10.1016/1044-0305(94)80016-2. ISSN 1044-0305. PMID 24226387.
  2. ↑ Washburn, Michael P.; Wolters, Dirk; Yates, John R. (March 2001). "Large-scale analysis of the yeast proteome by multidimensional protein identification technology". Nature Biotechnology. 19 (3): 242–247. doi:10.1038/85686. ISSN 1087-0156. PMID 11231557. S2CID 16796135.
  3. ↑ Venable, John D; Dong, Meng-Qiu; Wohlschlegel, James; Dillin, Andrew; Yates, John R (2004). "Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra". Nature Methods. 1 (1): 39–45. doi:10.1038/nmeth705. ISSN 1548-7091. PMID 15782151. S2CID 9780065.
  4. ↑ Pankow, Sandra; Bamberger, Casimir; Calzolari, Diego; Martínez-Bartolomé, Salvador; Lavallée-Adam, Mathieu; Balch, William E.; Yates, John R. (2015-12-24). "∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis". Nature. 528 (7583): 510–516. Bibcode:2015Natur.528..510P. doi:10.1038/nature15729. ISSN 0028-0836. PMC 4826614. PMID 26618866.
  5. ↑ Pankow, Sandra; Bamberger, Casimir; Yates, John R. (2019). "A posttranslational modification code for CFTR maturation is altered in cystic fibrosis". Science Signaling. 12 (562): eaan7984. doi:10.1126/scisignal.aan7984. ISSN 1945-0877. PMC 6464640. PMID 30600261.


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