Alexander Jon Stoessl[1] is a Canadian neurologist and Parkinson's disease researcher. He is the director of the Pacific Parkinson's Research Centre and Parkinson's Foundation Centre of Excellence at the University of British Columbia (UBC). He is also the head of the division of neurology at this university.[2] He is currently the President of the World Parkinson Coalition.

Early life and education

Stoessl was born in London, England.[3] In 1960, when Stoessl was a child, he and his family moved from England to London, Ontario, after his father was offered a job in Canada.[4] He received his medical degree from the University of Western Ontario in 1979, after which he completed an internship at McGill University and a residency in neurology at the University of Western Ontario, where he studied alongside Alastair Buchan.[4][5]

Career

In 1984, Stoessl joined the faculty of the University of British Columbia, where he worked on the positron emission tomography program with Donald Calne for two years.[5] He then worked at the Neuroscience Research Centre in the UK for two years in the late 1980s.[4] In 1996, he joined the faculty of UBC again, where he has remained ever since.[5]

Scientific work

In 2001, Stoessl published a paper in Science which found that the placebo effect in Parkinson's disease might be due to patients' anticipation of benefit, and that substantial dopamine is released in the brains of Parkinson's patients in response to placebo administration.[4][6] Subsequent research by Stoessl has found that dopamine is released in the brain of Parkinson's patients when they are given a placebo, but only if they are told the probability of it being a real drug is 75 percent.[7][8] He has said that "In Parkinson's, as in many other conditions, there is an important placebo response and that can be measured with clinical outcomes."[9]

Awards and honors

Stoessl holds a Canada Research Chair.[2] He was awarded the fourth annual Donald Calne Lectureship in 2006 by Parkinson Society Canada[3] and was named a Member of the Order of Canada in 2007.[4][5]

References

  1. ↑ Stoessl, Alexander Jon; Bushnell, Mary Catherine; Schulzer, Michael; Mak, Edwin; Troiano, Andre R.; Nandhagopal, R. (2010). "Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease". Pain Medicine. 11 (6): 834–840. doi:10.1111/j.1526-4637.2010.00866.x. ISSN 1526-2375. PMID 20624238.
  2. 1 2 "A. Jon Stoessl". UBC website. Retrieved 23 April 2015.
  3. 1 2 "Dr. A. Jon Stoessl recognized with 2006 Donald Calne Lectureship". Parkinson Society Saskatchewan. Retrieved 23 April 2015.
  4. 1 2 3 4 5 Holmes, D (November 2011). "Jon Stoessl: besotted with the brain". The Lancet. Neurology. 10 (11): 955. doi:10.1016/s1474-4422(11)70236-8. PMID 22014432. S2CID 12671041.
  5. 1 2 3 4 "Jon Stoessl". TRIUMF. Retrieved 23 April 2015.
  6. ↑ de la Fuente-Fernández, R; Ruth, TJ; Sossi, V; Schulzer, M; Calne, DB; Stoessl, AJ (10 August 2001). "Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease". Science. 293 (5532): 1164–6. doi:10.1126/science.1060937. PMID 11498597. S2CID 1477066.
  7. ↑ Lidstone, SC; Schulzer, M; Dinelle, K; Mak, E; Sossi, V; Ruth, TJ; de la Fuente-Fernández, R; Phillips, AG; Stoessl, AJ (August 2010). "Effects of expectation on placebo-induced dopamine release in Parkinson disease". Archives of General Psychiatry. 67 (8): 857–65. doi:10.1001/archgenpsychiatry.2010.88. PMID 20679593.
  8. ↑ Harding, Anne (4 August 2010). "Brain's reward system helps drive placebo effect". Reuters. Retrieved 23 April 2015.
  9. ↑ Bootle, Olly (17 February 2014). "The medicine in our minds". BBC News. Retrieved 23 April 2015.
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