KSR1

KSR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KBE, 1KBF, 2LPE
Identifiers
Aliases	KSR1, KSR, RSU2, kinase suppressor of ras 1
External IDs	OMIM: 601132 MGI: 105051 HomoloGene: 8410 GeneCards: KSR1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	27,626,438 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	79,037,233 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; sural nerve; ; oocyte; ; right lobe of thyroid gland; ; canal of the cervix; ; left lobe of thyroid gland; ; gallbladder; ; endothelial cell; ; stromal cell of endometrium; ; secondary oocyte;
	Top expressed in
	temporal muscle; ; triceps brachii muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; superior frontal gyrus; ; knee joint; ; skeletal muscle tissue; ; tibialis anterior muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein C-terminus binding; protein binding; ATP binding; MAP-kinase scaffold activity; protein kinase activity; signal transducer activity; mitogen-activated protein kinase kinase binding; chaperone binding; Hsp90 protein binding; 14-3-3 protein binding;
Cellular component	cytoplasm; cytosol; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; cell projection; ruffle membrane; plasma membrane; protein-containing complex;
Biological process	intracellular signal transduction; MAPK cascade; cAMP-mediated signaling; protein phosphorylation; Ras protein signal transduction; positive regulation of MAPK cascade; regulation of cell population proliferation; regulation of MAP kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	8844
	16706
	ENSG00000141068
	ENSMUSG00000018334
	Q8IVT5
	Q61097
	NM_014238; NM_001367810; NM_001394583; NM_001394584; NM_001394585
	NM_013571; NM_001348207
	NP_055053; NP_001354739
	NP_001335136; NP_038599
	Wikidata
View/Edit Human	View/Edit Mouse

Kinase suppressor of Ras 1 is an enzyme that in humans is encoded by the KSR1 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141068 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018334 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM (Jan 1996). "KSR, a novel protein kinase required for RAS signal transduction". Cell. 83 (6): 879–88. doi:10.1016/0092-8674(95)90204-X. PMID 8521512. S2CID 16975824.
↑ "Entrez Gene: KSR1 kinase suppressor of ras 1".

Goettel JA, Liang D, Hilliard VC, et al. (2011). "KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1". Exp. Cell Res. 317 (4): 452–63. doi:10.1016/j.yexcr.2010.11.018. PMC 3038243. PMID 21144847.
Kolesnick R, Xing HR (2004). "Inflammatory bowel disease reveals the kinase activity of KSR1". J. Clin. Invest. 114 (9): 1233–7. doi:10.1172/JCI23441. PMC 524240. PMID 15520853.
Xing HR, Lozano J, Kolesnick R (2000). "Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras". J. Biol. Chem. 275 (23): 17276–80. doi:10.1074/jbc.C900989199. PMID 10764733.
Roy F, Therrien M (2002). "MAP kinase module: the Ksr connection". Curr. Biol. 12 (9): R325–7. doi:10.1016/S0960-9822(02)00831-X. PMID 12007434. S2CID 17763459.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Matheny SA, Chen C, Kortum RL, et al. (2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP". Nature. 427 (6971): 256–60. Bibcode:2004Natur.427..256M. doi:10.1038/nature02237. PMID 14724641. S2CID 4416552.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kim M, Yan Y, Kortum RL, et al. (2005). "Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity". Cancer Res. 65 (10): 3986–92. doi:10.1158/0008-5472.CAN-03-2334. PMID 15899786.
Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature. 440 (7087): 1045–9. Bibcode:2006Natur.440.1045Z. doi:10.1038/nature04689. PMC 2610434. PMID 16625196.
Wang X, Wang TT, White JH, Studzinski GP (2006). "Induction of kinase suppressor of RAS-1(KSR-1) gene by1, α25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5′-flanking region". Oncogene. 25 (53): 7078–85. doi:10.1038/sj.onc.1209697. PMC 2843694. PMID 16732322.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000141068 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018334 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8521512-5] Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM (Jan 1996). "KSR, a novel protein kinase required for RAS signal transduction". Cell. 83 (6): 879–88. doi:10.1016/0092-8674(95)90204-X. PMID 8521512. S2CID 16975824.

[entrez-6] "Entrez Gene: KSR1 kinase suppressor of ras 1".

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[3]

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Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading