Kiana Aran
Alma materCity College of New York
Rutgers University
Scientific career
InstitutionsCardea
University of California, Berkeley
Keck Graduate Institute
ThesisDevelopment of microfluidic platform for continuous extraction of diagnostics plasma proteins from whole blood during cardiac surgery (2012)

Kiana Aran is an American biomedical entrepreneur who is Associate Professor in Medical Diagnostics at the Keck Graduate Institute. She is also the Chief Scientific Officer at Cardea Bio. Her research considers the application of two dimensional materials in disease detection and diagnosis. She was awarded the 2021 Nature – Estée Lauder Research Award for Inspiring Women in Science.

Early life and education

Aran was an undergraduate student at City College of New York and majored in electrical engineering.[1] She was a graduate student at Rutgers University, where she focused on biomedical engineering. For her doctoral research she worked on a microfluidic platform for the extraction of diagnostic plasma proteins.[2] The microfluidic platform was designed to work in a clinical environment and offer the continuous monitoring of the inflammatory response of patients undergoing cardiac surgeries.[2] The system designed by Aran comprised a two-compartment mass chamber, which allows for the continuous separation of blood plasma from blood cells with no evidence of cell lysis. A 200 nm pore size membrane can extract 15% of pure plasma at high sampling frequencies.[2] She moved to the University of California, Berkeley as a graduate student, where she worked on bioelectronics.[3]

Research and career

Aran has continued to develop novel biosensing platforms. She invented the CRISPR-chip, an electronic sensor that uses CRISPR-Cas to scan genomes and samples of nucleic acid for disease mutations.[3][4] The chip integrates Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) with single molecule graphene field-effect transistors to generate electronic signals when CRISPR interacts with target DNA/RNA.[5][6] She has demonstrated that the CRISPR-Chip can detect the mutations associated with sickle cell and Duchenne muscular dystrophy.[3]

Aran is co-founder and Chief Scientific Officer of Cardea, a biotechnology company.[7]

Awards and honors

  • 2020 Clinical OMICs 10 under 40 Award[8]
  • 2020 Athena Pinnacle Award[9]
  • 2021 NSF Career Award[10]
  • 2021 Nature Research Awards for Inspiring Women in Science[11]

Selected publications

  • Reza Hajian; Sarah Balderston; Thanhtra Tran; et al. (March 25, 2019), Detection of unamplified target genes via CRISPR-Cas9 immobilized on a graphene field-effect transistor, vol. 3, pp. 427–437, doi:10.1038/S41551-019-0371-X, PMC 6556128, PMID 31097816, Wikidata Q92091982
  • Kiana Aran; Lawrence A Sasso; Neal Kamdar; Jeffrey D Zahn (January 7, 2010). "Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevices". Lab on a Chip. 10 (5): 548–552. doi:10.1039/B924816A. ISSN 1473-0197. PMC 4538600. PMID 20162227. Wikidata Q35961114.
  • Kiana Aran; Alex Fok; Lawrence A Sasso; Neal Kamdar; Yulong Guan; Qi Sun; Akif Ündar; Jeffrey D Zahn (July 12, 2011). "Microfiltration platform for continuous blood plasma protein extraction from whole blood during cardiac surgery". Lab on a Chip. 11 (17): 2858–2868. doi:10.1039/C1LC20080A. ISSN 1473-0197. PMC 4538598. PMID 21750810. Wikidata Q35961102.

References

  1. ↑ "Kiana Aran". Keck Graduate Institute. Retrieved November 3, 2021.
  2. 1 2 3 Aran, Kiana; Rutgers University; Graduate School--New Brunswick (2012). Development of microfluidic platform for continuous extraction of diagnostics plasma proteins from whole blood during cardiac surgery. OCLC 785706174.
  3. 1 2 3 "News: CRISPR-Chip Inventor Kiana Aran Wins Major Women in Science Award". CRISPR Medicine. Retrieved November 3, 2021.
  4. ↑ "Dr. Kiana Aran of Cardea Bio wins the 2021 Nature Research Award for Scientific Achievement". uk.finance.yahoo.com. Retrieved November 3, 2021.
  5. ↑ "Dr. Kiana Aran Receives Prestigious NSF Career Award". Keck Graduate Institute. February 24, 2021. Retrieved November 3, 2021.
  6. ↑ Hajian, Reza; Balderston, Sarah; Tran, Thanhtra; deBoer, Tara; Etienne, Jessy; Sandhu, Mandeep; Wauford, Noreen A.; Chung, Jing-Yi; Nokes, Jolie; Athaiya, Mitre; Paredes, Jacobo (June 2019). "Detection of unamplified target genes via CRISPR–Cas9 immobilized on a graphene field-effect transistor". Nature Biomedical Engineering. 3 (6): 427–437. doi:10.1038/s41551-019-0371-x. ISSN 2157-846X. PMC 6556128. PMID 31097816.
  7. ↑ "Dr. Kiana Aran of Cardea Bio wins the 2021 Nature Research Award for Scientific Achievement". www.businesswire.com. October 28, 2021. Retrieved November 3, 2021.
  8. ↑ Writer, Clinical OMICs Staff (March 24, 2020). "The Clinical OMICs 10 Under 40". Clinical OMICs - Molecular Diagnostics in Precision Medicine. Retrieved November 3, 2021.
  9. ↑ "Athena | LWC Summit & Pinnacle Awards". Athena. Retrieved November 3, 2021.
  10. ↑ "Columbus librarian receives prestigious award". PsycEXTRA Dataset. 2004. doi:10.1037/e562792009-002. Retrieved November 3, 2021.
  11. ↑ "Dr. Kiana Aran's Achievements as a Biotech Leader Honored in 2021 Nature Research Awards for Inspiring Women in Science". Keck Graduate Institute. October 28, 2021. Retrieved November 3, 2021.
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