Kv channel interacting proteins are members of a family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[1] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[2]
Members of this family include:
- KCNIP1, a protein that in humans is encoded by the KCNIP1 gene.[3][2]
- KCNIP2, a protein that in humans is encoded by the KCNIP2 gene.[3][2]
- KCNIP3, more commonly known as Calsenilin, a protein that in humans is encoded by the KCNIP3 gene.[4][5][2]
- KCNIP4, a protein that in humans is encoded by the KCNIP4 gene.[6][7][2]
References
- ↑ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
- 1 2 3 4 5 "Entrez Gene: KCNIP1 Kv channel interacting protein 1".
- 1 2 An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–556. Bibcode:2000Natur.403..553A. doi:10.1038/35000592. PMID 10676964. S2CID 4419472.
- ↑ Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W (October 1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat Med. 4 (10): 1177–81. doi:10.1038/2673. PMID 9771752. S2CID 10799492.
- ↑ Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature. 398 (6722): 80–4. Bibcode:1999Natur.398...80C. doi:10.1038/18044. PMID 10078534. S2CID 204991618.
- ↑ Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, An WF (Jan 2002). "Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain". Proc Natl Acad Sci U S A. 99 (2): 1035–40. Bibcode:2002PNAS...99.1035H. doi:10.1073/pnas.022509299. PMC 117799. PMID 11805342.
- ↑ Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T (Apr 2002). "Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4". J Biol Chem. 277 (17): 14965–75. doi:10.1074/jbc.M200897200. PMID 11847232.
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