| LCTL | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | LCTL, KLG, KLPH, lactase like | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 617060 MGI: 2183549 HomoloGene: 70710 GeneCards: LCTL | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Lactase-like is a protein that in humans is encoded by the LCTL gene.[5] Lactase-like is a glycosidase enzyme.
Function
This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000188501 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032401 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: Lactase-like". Retrieved 2013-09-25.
Further reading
- Kim J, Eskiocak U, Stadler G, Lou Z, Kuro-o M, Shay JW, Wright WE (December 2011). "Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells". The Journal of Biological Chemistry. 286 (50): 43294–300. doi:10.1074/jbc.M111.267641. PMC 3234855. PMID 22020932.
- Mian IS (June 1998). "Sequence, structural, functional, and phylogenetic analyses of three glycosidase families". Blood Cells, Molecules & Diseases. 24 (2): 83–100. doi:10.1006/bcmd.1998.9998. PMID 9779294.
- Ito S, Fujimori T, Hayashizaki Y, Nabeshima Y (July 2002). "Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1576 (3): 341–5. doi:10.1016/S0167-4781(02)00281-6. PMID 12084582.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.