| LGSN | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | LGSN, GLULD1, LGS, lengsin, lens protein with glutamine synthetase domain | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611470 MGI: 2672844 HomoloGene: 9569 GeneCards: LGSN | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Lengsin is a protein that in humans is encoded by the LGSN gene.
Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re-engineering for a tissue-specific, noncatalytic role in the lens of the vertebrate eye.[5] Lengsin is the result of the recruitment of an ancient enzyme may act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. It does not seem to have enzymatic activity.
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000146166 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050217 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Wyatt K, Gao C, Tsai JY, Fariss RN, Ray S, Wistow G (March 2008). "A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens". The Journal of Biological Chemistry. 283 (10): 6607–15. doi:10.1074/jbc.M709144200. PMC 2911820. PMID 18178558.
Further reading
- Wyatt K, White HE, Wang L, Bateman OA, Slingsby C, Orlova EV, Wistow G (December 2006). "Lengsin is a survivor of an ancient family of class I glutamine synthetases re-engineered by evolution for a role in the vertebrate lens". Structure. London, England. 14 (12): 1823–34. doi:10.1016/j.str.2006.10.008. PMC 1868402. PMID 17161372.
External links
- "Q5TDP6 (LGSN_HUMAN)". UniProtKB.
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