LOC642658

SCX
Identifiers
Aliases	SCX, SCXA, SCXB, bHLHa48, LOC642658, scleraxis bHLH transcription factor
External IDs	OMIM: 609067 MGI: 102934 HomoloGene: 85195 GeneCards: SCX
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,268,481 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,343,658 bp
RNA expression pattern
	Top expressed in
	thymus; ; quadriceps femoris muscle; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; Achilles tendon; ; anterior pituitary; ; ascending aorta; ; skeletal muscle tissue; ; left ventricle; ; gastrocnemius muscle;
	Top expressed in
	toe; ; metatarsal bones; ; interventricular septum; ; plantaris muscle; ; extensor digitorum longus muscle; ; extraocular muscle; ; phalanx of foot; ; sternum; ; urethra; ; soleus muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; protein dimerization activity; bHLH transcription factor binding; E-box binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleus;
Biological process	cellular response to transforming growth factor beta stimulus; positive regulation of collagen biosynthetic process; cell differentiation; regulation of transcription, DNA-templated; chondrocyte differentiation; regulation of cartilage development; positive regulation of gastrulation; collagen fibril organization; tendon development; tendon cell differentiation; mesoderm formation; cellular response to BMP stimulus; negative regulation of apoptotic process; Sertoli cell differentiation; endochondral ossification; transcription by RNA polymerase II; BMP signaling pathway; transcription, DNA-templated; sclerotome development; embryonic skeletal system development; positive regulation of transcription, DNA-templated; multicellular organism development; deltoid tuberosity development; cellular response to mechanical stimulus; positive regulation of gene expression; heart valve formation; positive regulation of cartilage development; heart valve morphogenesis; tissue homeostasis; positive regulation of cell population proliferation; tendon formation; skeletal muscle cell differentiation; negative regulation of transcription, DNA-templated; face morphogenesis; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	642658
	20289
	ENSG00000260428
	ENSMUSG00000034161
	Q7RTU7
	Q64124
	NM_001008271; NM_001080514
	NM_198885
	NP_001073983
	NP_942588
	Wikidata
View/Edit Human	View/Edit Mouse

Basic helix-loop-helix transcription factor scleraxis is a protein that in humans is encoded by the SCXB gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000260428 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034161 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: LOC642658 similar to Basic helix-loop-helix transcription factor scleraxis".

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000260428 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034161 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LOC642658 similar to Basic helix-loop-helix transcription factor scleraxis".

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