LYK5

STRADA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UPK, 2WTK, 3GNI
Identifiers
Aliases	STRADA, LYK5, NY-BR-96, PMSE, STRAD, Stlk, STE20-related kinase adaptor alpha, STRAD alpha, STE20 related adaptor alpha
External IDs	OMIM: 608626 MGI: 1919399 HomoloGene: 12448 GeneCards: STRADA
Gene location (Human)
Chr.	Chromosome 17 (human)
End	63,741,986 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,092,994 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; gastric mucosa; ; tibial nerve; ; ganglionic eminence; ; Brodmann area 9; ; canal of the cervix; ; anterior pituitary; ; right lobe of thyroid gland; ; sural nerve; ; skin of abdomen;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; spermatid; ; morula; ; superior frontal gyrus; ; secondary oocyte; ; neural tube; ; yolk sac; ; blastocyst; ; cerebellar cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein serine/threonine kinase activator activity; protein kinase activator activity; protein kinase activity; ATP binding; nucleotide binding; kinase binding; protein serine/threonine kinase activity;
Cellular component	nucleoplasm; nucleus; cytoplasm; cytosol;
Biological process	protein export from nucleus; cell cycle; protein phosphorylation; positive regulation of protein serine/threonine kinase activity; activation of protein kinase activity; regulation of mitotic cell cycle; stress-activated protein kinase signaling cascade; regulation of apoptotic process; MAPK cascade; signal transduction; neuron projection morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	92335
	72149
	ENSG00000266173
	ENSMUSG00000069631
	Q7RTN6
	Q3UUJ4
NM_001003786; NM_001003787; NM_001003788; NM_001165969; NM_001165970;
	NM_153335; NM_001363786; NM_001363787; NM_001363788; NM_001363789; NM_001363790; NM_001363791
	NM_001252448; NM_001252449; NM_028126
NP_001003786; NP_001003787; NP_001003788; NP_001159441; NP_001159442;
	NP_699166; NP_001350715; NP_001350716; NP_001350717; NP_001350718; NP_001350719; NP_001350720
	NP_001239377; NP_001239378; NP_082402
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase LYK5, also known as LYK5 or STRADα, is a human protein and also denotes the gene encoding it.^[5]^[6]

Function

Endogenous LKB1 and STRADα form a complex in which STRADα activates LKB1, resulting in phosphorylation of both partners. Removal of endogenous LYK5 by small interfering RNA abrogates LKB1-induced G1 phase arrest.^[6] STRADα stabilizes LKB1 protein both in vivo and in vitro, and is capable of eliciting multiple axons in mouse embryonic cortical cultured neurons when overexpressed with LKB1. STRADα is highly spliced in vivo, and this is both developmentally regulated and tissue-specific, but the unique functions of the splice variants are not yet understood.^[7]

Disease linkage

Mutations in the LYK5/STRADα gene are associated with polyhydramnios, megalencephaly and symptomatic epilepsy (collectively known as the PMSE syndrome).^[8]

Interactions

STRADα has been shown to interact with LKB1 and MO25.^[6]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000266173 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000069631 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: LYK5 protein kinase LYK5".
1 2 3 Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC (June 2003). "Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD". EMBO J. 22 (12): 3062–72. doi:10.1093/emboj/cdg292. PMC 162144. PMID 12805220.
↑ Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP (2014). "STRAD pseudokinases regulate axogenesis and LKB1 stability". Neural Dev. 9 (5): 5. doi:10.1186/1749-8104-9-5. PMC 4016016. PMID 24594058./
↑ Puffenberger EG, Strauss KA, Ramsey KE, Craig DW, Stephan DA, Robinson DL, Hendrickson CL, Gottlieb S, Ramsay DA, Siu VM, Heuer GG, Crino PB, Morton DH (July 2007). "Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5". Brain. 130 (Pt 7): 1929–41. doi:10.1093/brain/awm100. PMID 17522105.
↑ Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR (Dec 2004). "Analysis of the LKB1-STRAD-MO25 complex". J. Cell Sci. 117 (Pt 26): 6365–75. doi:10.1242/jcs.01571. PMID 15561763.

Baas AF, Smit L, Clevers H (2004). "LKB1 tumor suppressor protein: PARtaker in cell polarity". Trends Cell Biol. 14 (6): 312–9. doi:10.1016/j.tcb.2004.04.001. PMID 15183188.
Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. PMID 12747765.
Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC (2003). "Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD". EMBO J. 22 (12): 3062–72. doi:10.1093/emboj/cdg292. PMC 162144. PMID 12805220.
Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR (2003). "MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". EMBO J. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473. PMID 14517248.
Milburn CC, Boudeau J, Deak M, Alessi DR, van Aalten DM (2004). "Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor". Nat. Struct. Mol. Biol. 11 (2): 193–200. doi:10.1038/nsmb716. PMID 14730349. S2CID 18401688.
Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR (2005). "Analysis of the LKB1-STRAD-MO25 complex". J. Cell Sci. 117 (Pt 26): 6365–75. doi:10.1242/jcs.01571. PMID 15561763.
Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP (2014). "STRAD pseudokinases regulate axogenesis and LKB1 stability". Neural Dev. 9 (5): 5. doi:10.1186/1749-8104-9-5. PMC 4016016. PMID 24594058.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000266173 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000069631 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LYK5 protein kinase LYK5".

[pmid12805220-6] 1 2 3 Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC (June 2003). "Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD". EMBO J. 22 (12): 3062–72. doi:10.1093/emboj/cdg292. PMC 162144. PMID 12805220.

[7] Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP (2014). "STRAD pseudokinases regulate axogenesis and LKB1 stability". Neural Dev. 9 (5): 5. doi:10.1186/1749-8104-9-5. PMC 4016016. PMID 24594058./

[pmid17522105-8] Puffenberger EG, Strauss KA, Ramsey KE, Craig DW, Stephan DA, Robinson DL, Hendrickson CL, Gottlieb S, Ramsay DA, Siu VM, Heuer GG, Crino PB, Morton DH (July 2007). "Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5". Brain. 130 (Pt 7): 1929–41. doi:10.1093/brain/awm100. PMID 17522105.

[pmid15561763-9] Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR (Dec 2004). "Analysis of the LKB1-STRAD-MO25 complex". J. Cell Sci. 117 (Pt 26): 6365–75. doi:10.1242/jcs.01571. PMID 15561763.

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Function

Disease linkage

Interactions

References

Further reading