Leucine-responsive regulatory protein
Structure of Escherichia coli Leucine-responsive regulatory protein
Identifiers
OrganismEscherichia coli
Symbollrp
Entrez949051
RefSeq (mRNA)NC_000913.3
RefSeq (Prot)NP_415409.1
UniProtP0ACJ0
Other data
ChromosomeGenomic: 0.03 - 0.03 Mb
Search for
StructuresSwiss-model
DomainsInterPro

Leucine responsive protein, or Lrp,[1] is a global regulator protein, meaning that it regulates the biosynthesis of leucine, as well as the other branched-chain amino acids, valine and isoleucine. In bacteria, it is encoded by the lrp gene.

Lrp alternatively activates and represses the expression of acetolactate synthase's (ALS) several isoenzymes. Lrp, in E. coli, along with DAM plays a role in the regulation of the fim operon, a group of genes needed for successful synthesis and trafficking of Type I Pili.[2] These hair like structures are important virulence factors for different pathogenic strains of Bacteria as they can mediate biofilm formation and adhesion to host epithelia. Other examples include Salmonella enterica serovar Typhimurium and Klebsiella pneumoniae.[2]

More generally, Lrp facilitates the proliferation and pathogenesis of bacteria in their hosts.[3]

Lrp in E. coli

Lrp plays a crucial role as a significant regulator in E. coli and other bacterial species. The E. coli Lrp is the most extensively researched member of the Lrp family. Its role includes the detection of changes and variations in nutrient conditions and is in charge of regulating the coordination relating to virulence, cellular motility, and nutrient acquisition.[1]

References

  1. 1 2 de los Rios S, Perona JJ (March 2007). "Structure of the Escherichia coli leucine-responsive regulatory protein Lrp reveals a novel octameric assembly". Journal of Molecular Biology. 366 (5): 1589–1602. doi:10.1016/j.jmb.2006.12.032. PMC 1933502. PMID 17223133.
  2. 1 2 Dorman CJ, Corcoran CP (February 2009). "Bacterial DNA topology and infectious disease". Nucleic Acids Research. 37 (3): 672–678. doi:10.1093/nar/gkn996. PMC 2647292. PMID 19073701.
  3. ↑ Baek CH, Wang S, Roland KL, Curtiss R (February 2009). "Leucine-responsive regulatory protein (Lrp) acts as a virulence repressor in Salmonella enterica serovar Typhimurium". Journal of Bacteriology. 191 (4): 1278–1292. doi:10.1128/JB.01142-08. PMC 2631999. PMID 19074398.
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