Lezanne Ooi
Alma materUniversity of Leeds
University of York
Known forNeuroscience
Scientific career
InstitutionsUniversity of Wollongong
University of Leeds
ThesisAn analysis of repressor element 1- silencing transcription factor interactions with its target genes (2005)

Lezanne Ooi is an Australian neuroscientist who is Professor and Head of Neurodevelopment at the University of Wollongong. Her research considers the development of cellular imaging techniques to understand neurodegenerative disease.

Early life and education

Ooi trained in the United Kingdom. She studied biochemistry at the University of York, where she worked with GlaxoSmith Kline.[1] When Ooi was studying neuroscience, her grandmother was diagnosed with dementia, which motivated her to purse a career studying neurodegenerative disease.[2][3] She completed her doctoral research on the transcriptional repressor REST (Repressor Element 1-Silencing Transcription factor) at the University of Leeds.[1][4] She remained there as a postdoctoral researcher, where she studied cardiac hypertrophy and developed cellular imaging techniques to understand neuronal function.[1] Her research showed that atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) became abnormally high in people with hypertrophy, and that an increase in REST could halt the rise of the other proteins.[5]

Research and career

In 2012, Ooi joined the University of Wollongong as a professor of neuroscience. Her lab has characterised over 100 induced pluripotent stem cell lines. She has studied various neurological conditions, including motor neuron diseases and vanishing white matter disease, a form of leukodystrophy.[6][7][8] She studied how COVID-19 impacted the likelihood of contracting dementia.[9]

In 2022, Ooi was awarded funding from the Michael J. Fox Foundation to study Parkinson's disease.[10][11] Her research considers the neuronal changes that place during neurodegenerative disease. She believes that Parkinson's causes changes in cell lipids and metabolites; which could be used as biomarkers of disease.[11]

Selected publications

  • G. D. Smith; M. J. Gunthorpe; R. E. Kelsell; et al. (23 June 2002). "TRPV3 is a temperature-sensitive vanilloid receptor-like protein". Nature. 418 (6894): 186–190. doi:10.1038/NATURE00894. ISSN 1476-4687. PMID 12077606. Wikidata Q40723123.
  • Lezanne Ooi; Ian C Wood (July 2007). "Chromatin crosstalk in development and disease: lessons from REST". Nature Reviews Genetics. 8 (7): 544–54. doi:10.1038/NRG2100. ISSN 1471-0056. PMID 17572692. Wikidata Q28306534.
  • Chiara Zuccato; Nikolai Belyaev; Paola Conforti; et al. (1 June 2007). "Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease". The Journal of Neuroscience. 27 (26): 6972–6983. doi:10.1523/JNEUROSCI.4278-06.2007. ISSN 0270-6474. PMC 6672230. PMID 17596446. Wikidata Q39333674.

References

  1. 1 2 3 "Changes in neuronal excitability and proteostasis in neurodegenerative disease | News & Events". newsevents.med.unsw.edu.au. Retrieved 2023-06-04.
  2. ↑ "Professor Lezanne Ooi | Australian Journal of Dementia Care". journalofdementiacare.com. Retrieved 2023-06-04.
  3. ↑ "2014: Talking brains over a beer - University of Wollongong – UOW". www.uow.edu.au. Retrieved 2023-06-04.
  4. ↑ "An analysis of repressor element 1- silencing transcription factor interactions with its target genes | WorldCat.org". www.worldcat.org. Retrieved 2023-06-04.
  5. ↑ "Breakthrough For Treatment Of Fatal Heart Condition". ScienceDaily. Retrieved 2023-06-04.
  6. ↑ Drewitt-Smith, Ainslie (2020-11-18). "Girl whose rare vanishing white matter disease triggered a search for a cure dies". ABC News. Retrieved 2023-06-04.
  7. ↑ Latifi, Agron (2020-04-24). "Illawarra walkers rally for Vanishing White Matter Disease research". Illawarra Mercury. Retrieved 2023-06-04.
  8. ↑ Wachsmuth, Lisa (2020-02-06). "Hope for families after breakthrough into Vanishing White Matter disease". Illawarra Mercury. Retrieved 2023-06-04.
  9. ↑ Mannix, Liam (2022-10-01). "Does contracting COVID make you more likely to develop dementia?". The Sydney Morning Herald. Retrieved 2023-06-04.
  10. ↑ "Michael J. Fox and Shake It Up fund scientist's research". Mirage News. 2023-04-03. Retrieved 2023-06-04.
  11. 1 2 "2022: Cracking the code for Parkinson's, one cell at a time - University of Wollongong – UOW". www.uow.edu.au. Retrieved 2023-06-04.
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