Lipid-phosphate phosphatase
Identifiers
EC no.3.1.3.76
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme lipid-phosphate phosphatase[1][2][3][4] (EC 3.1.3.76) catalyzes the reaction

(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase. Other names in common use include hydroxy fatty acid phosphatase, dihydroxy fatty acid phosphatase, hydroxy lipid phosphatase, sEH (ambiguous), and soluble epoxide hydrolase (ambiguous).

See also

References

    • Newman JW, Morisseau C, Harris TR, Hammock BD (2003). "The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1558–63. Bibcode:2003PNAS..100.1558N. doi:10.1073/pnas.0437724100. PMC 149871. PMID 12574510.
  1. Oesch F, Arand M (2003). "The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1552–7. Bibcode:2003PNAS..100.1552C. doi:10.1073/pnas.0437829100. PMC 149870. PMID 12574508.
  2. Newman JW, Morisseau C, Harris TR, Hammock BD (2003). "The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1558–63. Bibcode:2003PNAS..100.1558N. doi:10.1073/pnas.0437724100. PMC 149871. PMID 12574510.
  3. Oesch F, Arand M (2003). "The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1552–7. Bibcode:2003PNAS..100.1552C. doi:10.1073/pnas.0437829100. PMC 149870. PMID 12574508.


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