MEAF6

MEAF6
Identifiers
Aliases	MEAF6, C1orf149, CENP-28, EAF6, NY-SAR-91, MYST/Esa1 associated factor 6
External IDs	OMIM: 611001 MGI: 1917338 HomoloGene: 11240 GeneCards: MEAF6
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,514,766 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	125,007,031 bp
RNA expression pattern
	Top expressed in
	oocyte; ; ganglionic eminence; ; Achilles tendon; ; anterior pituitary; ; pons; ; secondary oocyte; ; islet of Langerhans; ; seminal vesicula; ; prefrontal cortex; ; bronchial epithelial cell;
	Top expressed in
	superior cervical ganglion; ; superior frontal gyrus; ; hand; ; neural tube; ; otolith organ; ; ganglionic eminence; ; utricle; ; morula; ; thymus; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; histone acetyltransferase activity (H3-K23 specific);
Cellular component	NuA4 histone acetyltransferase complex; MOZ/MORF histone acetyltransferase complex; histone acetyltransferase complex; nucleus; nucleolus; chromosome; kinetochore; chromosome, centromeric region; nucleoplasm; NuA3a histone acetyltransferase complex; NuA3b histone acetyltransferase complex;
Biological process	histone H4-K12 acetylation; regulation of transcription, DNA-templated; histone H4-K5 acetylation; histone acetylation; histone H4-K8 acetylation; histone H4-K16 acetylation; histone H3-K14 acetylation; histone H2A acetylation; transcription, DNA-templated; regulation of signal transduction by p53 class mediator; chromatin organization; histone H3-K23 acetylation;
	Sources:Amigo / QuickGO
Orthologs
	64769
	70088
	ENSG00000163875
	ENSMUSG00000028863
	Q9HAF1
	Q2VPQ9
	NM_001270875; NM_001270876; NM_022756
	NM_001290701; NM_027310; NM_001374123
	NP_001257804; NP_001257805; NP_073593
	NP_001277630; NP_081586; NP_001361052
	Wikidata
View/Edit Human	View/Edit Mouse

Chromatin modification-related protein MEAF6 is a protein that in humans is encoded by the MEAF6 gene.^[5]^[6]^[7]^[8]^[9]^[10]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163875 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028863 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
↑ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
↑ Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW (Oct 2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J Biol Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
↑ Doyon Y, Selleck W, Lane WS, Tan S, Cote J (Feb 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol Cell Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J (Jan 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Mol Cell. 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.
↑ "Entrez Gene: C1orf149 chromosome 1 open reading frame 149".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lee SY, Obata Y, Yoshida M, et al. (2003). "Immunomic analysis of human sarcoma". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2651–6. Bibcode:2003PNAS..100.2651L. doi:10.1073/pnas.0437972100. PMC 151395. PMID 12601173.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163875 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028863 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8619474-5] Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[pmid9110174-6] Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.

[pmid12963728-7] Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW (Oct 2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J Biol Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.

[pmid14966270-8] Doyon Y, Selleck W, Lane WS, Tan S, Cote J (Feb 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol Cell Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.

[pmid16387653-9] Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J (Jan 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Mol Cell. 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.

[entrez-10] "Entrez Gene: C1orf149 chromosome 1 open reading frame 149".

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References

Further reading