Meco may refer to:
- Meco (born 1939), American record producer and musician
- Meco (municipality), a part of metropolitan Madrid, Spain
MECO may stand for:
- Mactan Electric Company
- Metropolitan Edison, an electric utility serving regions of Pennsylvania, later acquired by GPU, and now part of FirstEnergy; Meco Road, bordering its property near Easton, Pennsylvania, is named for the company
- Main engine cutoff, the shut-off of the first stage in a multistage rocket
- Magnetospheric eternally collapsing object, a theoretical alternative to a black hole
- Middle European Cooperation in Statistical Physics, an international conference on statistical physics
- Middle Eocene Climatic Optimum, a global warming period 40 million years ago, during the Eocene
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