MICAL2

MICAL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E9K
Identifiers
Aliases	MICAL2, MICAL-2, MICAL2PV1, MICAL2PV2, microtubule associated monooxygenase, calponin and LIM domain containing 2
External IDs	OMIM: 608881 MGI: 2444947 HomoloGene: 8760 GeneCards: MICAL2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	12,359,144 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	112,413,106 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; right coronary artery; ; saphenous vein; ; ascending aorta; ; frontal pole; ; Region I of hippocampus proper; ; visceral pleura;
	Top expressed in
	superior frontal gyrus; ; ascending aorta; ; seminiferous tubule; ; aortic valve; ; spermatid; ; cerebellar cortex; ; atrium; ; lip; ; olfactory epithelium; ; pyloric antrum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	actin binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; FAD binding; metal ion binding; monooxygenase activity; oxidoreductase activity; NADPH:sulfur oxidoreductase activity; NAD(P)H oxidase H2O2-forming activity;
Cellular component	nucleus;
Biological process	heart looping; actin filament depolymerization; heart development; cytoskeleton organization; sulfur oxidation;
	Sources:Amigo / QuickGO
Orthologs
	9645
	320878
	ENSG00000133816
	ENSMUSG00000038244
	O94851
	Q8BML1
NM_001282663; NM_001282664; NM_001282665; NM_001282666; NM_001282667;
	NM_001282668; NM_001346292; NM_001346293; NM_001346294; NM_001346295; NM_001346296; NM_001346297; NM_001346298; NM_001346299; NM_014632
	NM_001193305; NM_177282
NP_001269592; NP_001269593; NP_001269594; NP_001269595; NP_001269596;
	NP_001269597; NP_001333221; NP_001333222; NP_001333223; NP_001333224; NP_001333225; NP_001333226; NP_001333227; NP_001333228; NP_055447
	NP_001180234; NP_796256
	Wikidata
View/Edit Human	View/Edit Mouse

Protein MICAL-2 is a protein that in humans is encoded by the MICAL2 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000133816 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038244 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Terman JR, Mao T, Pasterkamp RJ, Yu HH, Kolodkin AL (Jul 2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID 12110185.
↑ "Entrez Gene: MICAL2 microtubule associated monoxygenase, calponin and LIM domain containing 2".

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
Ashida S, Furihata M, Katagiri T, et al. (2006). "Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression". Clin. Cancer Res. 12 (9): 2767–73. doi:10.1158/1078-0432.CCR-05-1995. PMID 16675569.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000133816 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038244 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12110185-5] Terman JR, Mao T, Pasterkamp RJ, Yu HH, Kolodkin AL (Jul 2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID 12110185.

[entrez-6] "Entrez Gene: MICAL2 microtubule associated monoxygenase, calponin and LIM domain containing 2".

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References

Further reading