MINPP1

MINPP1
Identifiers
Aliases	MINPP1, HIPER1, MINPP2, MIPP, multiple inositol-polyphosphate phosphatase 1, PCH16
External IDs	OMIM: 605391 MGI: 1336159 HomoloGene: 37980 GeneCards: MINPP1
EC number	3.1.3.80
Gene location (Human)
Chr.	Chromosome 10 (human)
End	87,553,461 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	32,492,764 bp
RNA expression pattern
	Top expressed in
	spongy bone; ; tibia; ; islet of Langerhans; ; jejunal mucosa; ; kidney tubule; ; left adrenal gland; ; stromal cell of endometrium; ; right lobe of liver; ; placenta; ; bone marrow;
	Top expressed in
	abdominal wall; ; primitive streak; ; molar; ; seminal vesicula; ; endocardial cushion; ; skin of back; ; proximal tubule; ; sexually immature organism; ; hand; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatase activity; bisphosphoglycerate 3-phosphatase activity; inositol-hexakisphosphate phosphatase activity; hydrolase activity; inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; inositol hexakisphosphate 2-phosphatase activity; acid phosphatase activity; inositol phosphate phosphatase activity; protein histidine phosphatase activity;
Cellular component	endoplasmic reticulum lumen; endoplasmic reticulum; extracellular exosome;
Biological process	bone mineralization; polyphosphate metabolic process; inositol phosphate metabolic process; ossification; dephosphorylation; protein dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	9562
	17330
	ENSG00000107789
	ENSMUSG00000024896
	Q9UNW1
	Q9Z2L6
	NM_001178117; NM_001178118; NM_004897
	NM_010799
	NP_001171588; NP_001171589; NP_004888
	NP_034929
	Wikidata
View/Edit Human	View/Edit Mouse

Multiple inositol polyphosphate phosphatase 1 is an enzyme that in humans is encoded by the MINPP1 gene.^[5]^[6]

MINPP1 hydrolyzes the abundant metabolites inositol pentakisphosphate and inositol hexakisphosphate and, like PTEN (MIM 601728), has the ability to remove 3-phosphate from inositol phosphate substrates.[supplied by OMIM]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107789 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024896 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chi H, Tiller GE, Dasouki MJ, Romano PR, Wang J, O'keefe RJ, Puzas JE, Rosier RN, Reynolds PR (May 1999). "Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19". Genomics. 56 (3): 324–36. doi:10.1006/geno.1998.5736. PMID 10087200.
1 2 "Entrez Gene: MINPP1 multiple inositol polyphosphate histidine phosphatase, 1".

Romano PR, Wang J, O'Keefe RJ, et al. (1998). "HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation". J. Cell Sci. 111 (6): 803–13. doi:10.1242/jcs.111.6.803. PMID 9472008.
Caffrey JJ, Hidaka K, Matsuda M, et al. (1999). "The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification". FEBS Lett. 442 (1): 99–104. doi:10.1016/S0014-5793(98)01636-6. PMID 9923613. S2CID 7105717.
Chi H, Yang X, Kingsley PD, et al. (2000). "Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo". Mol. Cell. Biol. 20 (17): 6496–507. doi:10.1128/MCB.20.17.6496-6507.2000. PMC 86124. PMID 10938126.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Gimm O, Chi H, Dahia PL, et al. (2001). "Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas". J. Clin. Endocrinol. Metab. 86 (4): 1801–5. doi:10.1210/jcem.86.4.7419. PMID 11297621.
VanHouten JN, Asch HL, Asch BB (2001). "Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas". Oncogene. 20 (38): 5366–72. doi:10.1038/sj.onc.1204701. PMID 11536049. S2CID 6474518.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000107789 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024896 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10087200-5] Chi H, Tiller GE, Dasouki MJ, Romano PR, Wang J, O'keefe RJ, Puzas JE, Rosier RN, Reynolds PR (May 1999). "Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19". Genomics. 56 (3): 324–36. doi:10.1006/geno.1998.5736. PMID 10087200.

[entrez-6] 1 2 "Entrez Gene: MINPP1 multiple inositol polyphosphate histidine phosphatase, 1".

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References

Further reading