| MIR7-1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MIR7-1, MIRN7-1, hsa-mir-7-1, mir-7-1, MicroRNA 7-1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 615239 GeneCards: MIR7-1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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MicroRNA 7-1 is a microRNA molecule that in humans is encoded by the MIR7-1 gene.[3]
Function
microRNAs, or miRNAs, are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000284179 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: MicroRNA 7-1". National Center for Biotechnology Information. National Institutes of Health. Retrieved 26 December 2013.
Further reading
- Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP (March 2003). "Vertebrate microRNA genes". Science. 299 (5612): 1540. doi:10.1126/science.1080372. PMID 12624257. S2CID 37750545.
- Correa-Medina M, Bravo-Egana V, Rosero S, Ricordi C, Edlund H, Diez J, Pastori RL (April 2009). "MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas". Gene Expression Patterns. 9 (4): 193–9. doi:10.1016/j.gep.2008.12.003. PMID 19135553.
- Chen AX, Yu KD, Fan L, Li JY, Yang C, Huang AJ, Shao ZM (September 2011). Horwitz MS (ed.). "Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility". PLOS Genetics. 7 (9): e1002259. doi:10.1371/journal.pgen.1002259. PMC 3164678. PMID 21912531.
- Xu L, Wen Z, Zhou Y, Liu Z, Li Q, Fei G, Luo J, Ren T (January 2013). "MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway". Molecular Biology of the Cell. 24 (1): 42–55. doi:10.1091/mbc.E12-07-0519. PMC 3530778. PMID 23135998.
- Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, Lee J, Fine H, Chiocca EA, Lawler S, Purow B (May 2008). "microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma". Cancer Research. 68 (10): 3566–72. doi:10.1158/0008-5472.CAN-07-6639. PMID 18483236.
- Bravo-Egana V, Rosero S, Molano RD, Pileggi A, Ricordi C, Domínguez-Bendala J, Pastori RL (February 2008). "Quantitative differential expression analysis reveals miR-7 as major islet microRNA". Biochemical and Biophysical Research Communications. 366 (4): 922–6. doi:10.1016/j.bbrc.2007.12.052. PMC 4104201. PMID 18086561.
- Chen ZX, Sun AM, Chen Y, Liu Y, Zhan JF, Chen LH, Yuan YW (August 2010). "[Effects of radiosensitivity and X-ray dose on miR-7 expression in nasopharyngeal carcinoma]". Nan Fang Yi Ke da Xue Xue Bao = Journal of Southern Medical University. 30 (8): 1810–2, 1816. PMID 20813671.
- Kredo-Russo S, Ness A, Mandelbaum AD, Walker MD, Hornstein E (2012). "Regulation of pancreatic microRNA-7 expression". Experimental Diabetes Research. 2012: 695214. doi:10.1155/2012/695214. PMC 3362837. PMID 22675342.
- Wang Y, Liu J, Liu C, Naji A, Stoffers DA (March 2013). "MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells". Diabetes. 62 (3): 887–95. doi:10.2337/db12-0451. PMC 3581216. PMID 23223022.
- Midgley AC, Bowen T, Phillips AO, Steadman R (April 2014). "MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts". Aging Cell. 13 (2): 235–44. doi:10.1111/acel.12167. PMC 4331777. PMID 24134702.
- Midgley AC, Morris G, Phillips AO, Steadman R (June 2016). "17β-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-γ/STAT1-dependent miR-7 upregulation". Aging Cell. 15 (3): 531–41. doi:10.1111/acel.12462. PMC 4854905. PMID 26931423.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.