MMS19

MMS19
Identifiers
Aliases	MMS19, MET18, MMS19L, hMMS19 homolog, cytosolic iron-sulfur assembly component, CIAO4
External IDs	OMIM: 614777 MGI: 1919449 HomoloGene: 41480 GeneCards: MMS19
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,498,794 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,969,596 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; skin of abdomen; ; tibial nerve; ; ganglionic eminence; ; right lung; ; canal of the cervix; ; right lobe of thyroid gland; ; sural nerve; ; right uterine tube; ; left lobe of thyroid gland;
	Top expressed in
	superior frontal gyrus; ; thymus; ; lip; ; oocyte; ; secondary oocyte; ; ankle joint; ; spermatocyte; ; yolk sac; ; ganglionic eminence; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; transcription coactivator activity; protein binding; enzyme binding; signaling receptor complex adaptor activity; estrogen receptor binding;
Cellular component	membrane; nucleoplasm; transcription factor TFIIH holo complex; CIA complex; cytoskeleton; MMXD complex; nucleus; cytoplasm; spindle; cytosol;
Biological process	regulation of transcription, DNA-templated; chromosome segregation; DNA metabolic process; cellular response to DNA damage stimulus; positive regulation of transcription, DNA-templated; iron-sulfur cluster assembly; phosphorelay signal transduction system; response to hormone; DNA repair; nucleotide-excision repair; transcription, DNA-templated; protein maturation by iron-sulfur cluster transfer; positive regulation of double-strand break repair via homologous recombination; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	64210
	72199
	ENSG00000155229
	ENSMUSG00000025159
	Q96T76
	Q9D071
NM_001289403; NM_001289404; NM_001289405; NM_022362; NM_001330128;
	NM_001351356; NM_001351357; NM_001351358; NM_001351359
	NM_028152; NM_001373946
NP_001276332; NP_001276333; NP_001276334; NP_001317057; NP_071757;
	NP_001338285; NP_001338286; NP_001338287; NP_001338288
	NP_082428; NP_001360875
	Wikidata
View/Edit Human	View/Edit Mouse

MMS19 nucleotide excision repair protein homolog is a protein that in humans is encoded by the MMS19 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000155229 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025159 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Seroz T, Winkler GS, Auriol J, Verhage RA, Vermeulen W, Smit B, Brouwer J, Eker AP, Weeda G, Egly JM, Hoeijmakers JH (Nov 2000). "Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases". Nucleic Acids Res. 28 (22): 4506–13. doi:10.1093/nar/28.22.4506. PMC 113875. PMID 11071939.
↑ "Entrez Gene: MMS19L MMS19-like (MET18 homolog, S. cerevisiae)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wu X, Li H, Chen JD (2001). "The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor". J. Biol. Chem. 276 (26): 23962–8. doi:10.1074/jbc.M101041200. PMID 11279242.
Queimado L, Rao M, Schultz RA, et al. (2002). "Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant". Nucleic Acids Res. 29 (9): 1884–91. doi:10.1093/nar/29.9.1884. PMC 37259. PMID 11328871.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hatfield MD, Reis AM, Obeso D, et al. (2006). "Identification of MMS19 domains with distinct functions in NER and transcription". DNA Repair (Amst.). 5 (8): 914–24. doi:10.1016/j.dnarep.2006.05.007. PMID 16797255.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000155229 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025159 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11071939-5] Seroz T, Winkler GS, Auriol J, Verhage RA, Vermeulen W, Smit B, Brouwer J, Eker AP, Weeda G, Egly JM, Hoeijmakers JH (Nov 2000). "Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases". Nucleic Acids Res. 28 (22): 4506–13. doi:10.1093/nar/28.22.4506. PMC 113875. PMID 11071939.

[entrez-6] "Entrez Gene: MMS19L MMS19-like (MET18 homolog, S. cerevisiae)".

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References

Further reading