MOV10

MOV10
Identifiers
Aliases	MOV10, fSAP113, gb110, Mov10 RISC complex RNA helicase
External IDs	OMIM: 610742 MGI: 97054 HomoloGene: 10365 GeneCards: MOV10
Gene location (Human)
Chr.	Chromosome 1 (human)
End	112,700,756 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	104,725,879 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; anterior pituitary; ; right lobe of liver; ; skin of abdomen; ; spleen; ; right lobe of thyroid gland; ; canal of the cervix; ; left uterine tube; ; left lobe of thyroid gland; ; minor salivary gland;
	Top expressed in
	yolk sac; ; gallbladder; ; duodenum; ; ankle joint; ; ileum; ; jejunum; ; maxillary prominence; ; blastocyst; ; thymus; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; helicase activity; protein binding; hydrolase activity; ATP binding; RNA binding; 5'-3' RNA helicase activity;
Cellular component	cytoplasm; P-body; extracellular space; cytosol; nucleus; cytoplasmic stress granule; cytoplasmic ribonucleoprotein granule; P granule;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; mRNA destabilization-mediated gene silencing by miRNA; gene silencing; Wnt signaling pathway, calcium modulating pathway; gene silencing by miRNA; regulation of megakaryocyte differentiation; negative regulation of transposition, RNA-mediated; positive regulation of gene expression; negative regulation of gene expression; RNA interference; positive regulation of mRNA catabolic process; 3'-UTR-mediated mRNA destabilization; regulation of neuron projection arborization;
	Sources:Amigo / QuickGO
Orthologs
	4343
	17454
	ENSG00000155363
	ENSMUSG00000002227
	Q9HCE1
	P23249
NM_001130079; NM_001286072; NM_020963; NM_001321324; NM_001369507;
	NM_001389562; NM_001389563
	NM_001163440; NM_001163441; NM_008619
	NP_001123551; NP_001273001; NP_001308253; NP_066014; NP_001356436
	NP_001156912; NP_001156913; NP_032645
	Wikidata
View/Edit Human	View/Edit Mouse

Putative helicase MOV-10 is an enzyme that in humans is encoded by the MOV10 gene.^[5] Stability of MOV10 protein is controlled via DCAF12 ubiquitin ligase.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000155363 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002227 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MOV10 Mov10, Moloney leukemia virus 10, homolog (mouse)".
↑ Lidak, Tomas (20 May 2021). "CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation". Int J Mol Sci. 22 (10): 5394. doi:10.3390/ijms22105394. PMC 8161014. PMID 34065512.

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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
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Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Meister G, Landthaler M, Peters L, et al. (2006). "Identification of novel argonaute-associated proteins". Curr. Biol. 15 (23): 2149–55. doi:10.1016/j.cub.2005.10.048. hdl:11858/00-001M-0000-0012-E763-B. PMID 16289642. S2CID 2740901.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000155363 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002227 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MOV10 Mov10, Moloney leukemia virus 10, homolog (mouse)".

[6] Lidak, Tomas (20 May 2021). "CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation". Int J Mol Sci. 22 (10): 5394. doi:10.3390/ijms22105394. PMC 8161014. PMID 34065512.

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References

Further reading