MRPL20
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL20, L20mt, MRP-L20, mitochondrial ribosomal protein L20
External IDsOMIM: 611833 MGI: 2137221 HomoloGene: 9941 GeneCards: MRPL20
Orthologs
SpeciesHumanMouse
Entrez

55052

66448

Ensembl

ENSG00000242485

ENSMUSG00000029066

UniProt

Q9BYC9

Q9CQL4

RefSeq (mRNA)

NM_017971
NM_001318485

NM_025570

RefSeq (protein)

NP_001305414
NP_060441

NP_079846

Location (UCSC)Chr 1: 1.4 – 1.41 MbChr 4: 155.89 – 155.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L20, mitochondrial is a protein that in humans is encoded by the MRPL20 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000242485 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029066 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: MRPL20 mitochondrial ribosomal protein L20".

Further reading


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