MRPS18B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS18B, C6orf14, HSPC183, HumanS18a, MRP-S18-2, MRPS18-2, PTD017, S18amt, mitochondrial ribosomal protein S18B
External IDsOMIM: 611982 MGI: 1914223 HomoloGene: 32205 GeneCards: MRPS18B
Orthologs
SpeciesHumanMouse
Entrez

28973

66973

Ensembl

ENSMUSG00000024436

UniProt

Q9Y676

Q99N84

RefSeq (mRNA)

NM_014046

NM_025878
NM_001347380
NM_001361453
NM_001361454
NM_001361455

RefSeq (protein)

NP_054765

NP_001334309
NP_080154
NP_001348382
NP_001348383
NP_001348384

Location (UCSC)Chr 6: 30.62 – 30.63 MbChr 17: 36.22 – 36.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S18b, mitochondrial is a protein that in humans is encoded by the MRPS18B gene.[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.

Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q.[6]

References

  1. 1 2 3 ENSG00000226111, ENSG00000204568, ENSG00000203624, ENSG00000227420, ENSG00000233813, ENSG00000223775 GRCh38: Ensembl release 89: ENSG00000229861, ENSG00000226111, ENSG00000204568, ENSG00000203624, ENSG00000227420, ENSG00000233813, ENSG00000223775 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024436 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
  6. 1 2 "Entrez Gene: MRPS18B mitochondrial ribosomal protein S18B".

Further reading


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