| MTRF1L | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MTRF1L, HMRF1L, MRF1L, mtRF1a, mitochondrial translational release factor 1 like, mitochondrial translation release factor 1 like | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 613542 MGI: 1918830 HomoloGene: 5905 GeneCards: MTRF1L | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Mitochondrial translational release factor 1-like is a protein that in humans is encoded by the MTRF1L gene.[5]
Mitochondrial DNA encodes 13 proteins that play essential roles in the respiratory chain, while all proteins involved in mitochondrial translation are encoded by nuclear genes that are imported from the cytoplasm. MTRF1L is a nuclear-encoded protein that functions as a releasing factor that recognizes termination codons and releases mitochondrial ribosomes from the synthesized protein (summary by Nozaki et al., 2008 [PubMed 18429816]).[supplied by OMIM].[5]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000112031 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019774 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 "Entrez Gene: Mitochondrial translational release factor 1-like". Retrieved 2011-09-20.
Further reading
Soleimanpour-Lichaei, H. R.; Kühl, I.; Gaisne, M.; Passos, J. F.; Wydro, M.; Rorbach, J.; Temperley, R.; Bonnefoy, N.; Tate, W.; Lightowlers, R.; Chrzanowska-Lightowlers, Z. (2007). "MtRF1a is a Human Mitochondrial Translation Release Factor Decoding the Major Termination Codons UAA and UAG". Molecular Cell. 27 (5): 745–757. doi:10.1016/j.molcel.2007.06.031. PMC 1976341. PMID 17803939. Nozaki, Y.; Matsunaga, N.; Ishizawa, T.; Ueda, T.; Takeuchi, N. (2008). "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG". Genes to Cells. 13 (5): 429–438. doi:10.1111/j.1365-2443.2008.01181.x. PMID 18429816. S2CID 21204094. Ishizawa, T.; Nozaki, Y.; Ueda, T.; Takeuchi, N. (2008). "The human mitochondrial translation release factor HMRF1L is methylated in the GGQ motif by the methyltransferase HMPrmC". Biochemical and Biophysical Research Communications. 373 (1): 99–103. doi:10.1016/j.bbrc.2008.05.176. PMID 18541145. Vieira, A. R.; McHenry, T. G.; Daack-Hirsch, S.; Murray, J. C.; Marazita, M. L. (2008). "Candidate Gene/Loci Studies in Cleft Lip/Palate and Dental Anomalies Finds Novel Susceptibility Genes for Clefts". Genetics in Medicine. 10 (9): 668–674. doi:10.1097/GIM.0b013e3181833793. PMC 2734954. PMID 18978678. Antonicka, H.; Østergaard, E.; Sasarman, F.; Weraarpachai, W.; Wibrand, F.; Pedersen, A. M. B.; Rodenburg, R. J.; Van Der Knaap, M. S.; Smeitink, J. A. M.; Chrzanowska-Lightowlers, Z. M.; Shoubridge, E. A. (2010). "Mutations in C12orf65 in Patients with Encephalomyopathy and a Mitochondrial Translation Defect". The American Journal of Human Genetics. 87 (1): 115–122. doi:10.1016/j.ajhg.2010.06.004. PMC 2896764. PMID 20598281.