MZF1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMZF1, MZF-1, MZF1B, ZFP98, ZNF42, ZSCAN6, myeloid zinc finger 1
External IDsOMIM: 194550 MGI: 107457 HomoloGene: 9633 GeneCards: MZF1
Orthologs
SpeciesHumanMouse
Entrez

7593

109889

Ensembl

ENSG00000099326

ENSMUSG00000030380

UniProt

P28698

n/a

RefSeq (mRNA)

NM_001267033
NM_003422
NM_198055

NM_001290452
NM_001290453
NM_145819
NM_001382820
NM_016793

RefSeq (protein)

NP_001253962
NP_003413
NP_932172

n/a

Location (UCSC)Chr 19: 58.56 – 58.57 MbChr 7: 12.78 – 12.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myeloid zinc finger 1 is a protein that in humans is encoded by the MZF1 gene.[5][6]

Interactions

MZF1 has been shown to interact with SCAND1.[7] In 2014, the laboratory of Nathan H. Lents showed that MZF-1 induces the GAPDH gene, something that must be considered when GAPDH is used as a loading control in experiments that may induce or perturb MZF-1.[8] The same group later showed that MZF-1 induces CTGF and NOV, two members of the CCN gene family.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000099326 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030380 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K (September 1991). "A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells". J Biol Chem. 266 (22): 14183–7. doi:10.1016/S0021-9258(18)98664-3. PMID 1860835.
  6. "Entrez Gene: MZF1 myeloid zinc finger 1".
  7. Sander TL, Haas AL, Peterson MJ, Morris JF (April 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi:10.1074/jbc.275.17.12857. PMID 10777584.
  8. Piszczatowski RT, Rafferty BJ, Rozado A, Tobak S, Lents NH (2014). "The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol". Biochem. Biophys. Res. Commun. 451 (1): 137–41. doi:10.1016/j.bbrc.2014.07.082. PMID 25065746.
  9. Piszczatowski RT (2015). "Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of theCCN2/CTGFandCCN3/NOVGenes in the Hematopoietic Compartment". Journal of Cellular Physiology. 230 (11): 2634–2639. doi:10.1002/jcp.25021. PMID 25899830. S2CID 6888015.

Further reading


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