Malcolm K. Brenner is a British clinical scientist working mostly in the field of gene therapy and immunotherapy applied to malignancy. In 2016, Dr. Brenner was elected to the National Academy of Medicine,[1] part of the National Academies of Sciences, Engineering, and Medicine.

He was educated at Forest School, Walthamstow and Emmanuel College, Cambridge England. He received his medical degree and subsequent Ph.D. from Cambridge University, England. In the 1980s, he was a Lecturer in Hematology at Royal Free Hospital in London. In 1990, he left the UK to work in St. Jude Children's Research Hospital in Memphis as the director of the Bone Marrow Transplant Division.

There, he conducted one of the first human gene therapy studies when he transduced bone marrow stem cells with a retroviral vector with the intention of marking them to study their survival and fate. This seminal study demonstrated that engrafted bone marrow stem cells contribute to long-term hematopoiesis and also that contaminating tumor cells in autografts can cause relapse. In 1994, he became the director of St. Jude's Cell and Gene Therapy Program.

The move in 1994 reflected his growing interest in the genetic-modification of T-cells for cancer therapy, cancer vaccines and monoclonal antibodies.[2]

He was President of the International Society for Cellular Therapy and President of the American Society of Gene Therapy in 2002–2003. He was appointed Editor in Chief of the journal Molecular Therapy in 2009.[3]

Dr. Brenner was appointed Director of the Center for Cell and Gene Therapy. Dr. Brenner's is a full-time faculty member for the Center for Cell and Gene Therapy, Texas Children's Cancer Center and the Dan L. Duncan Cancer Center at Baylor College of Medicine, Houston, Texas.[4] In 2017, Dr. Brenner was awarded the European Society of Gene and Cell Therapy Outstanding Achievement Award,[5] and in 2020 the Career Achievement Award in Cell & Gene Therapy from the International Society of Cell and Gene Therapy.[6]

References

  1. ↑ "National Academy of Medicine Elects 80 New Members". 17 October 2016.
  2. ↑ Koehler, M; Hurwitz, CA; Krance, RA; Coustan-Smith, E; Williams, LL; Santana, V; Ribeiro, RC; Brenner, MK; Heslop, HE (1994). "XomaZyme-CD5 immunotoxin in conjunction with partial T cell depletion for prevention of graft rejection and graft-versus-host disease after bone marrow transplantation from matched unrelated donors". Bone Marrow Transplant. 13 (5): 571–5. PMID 7519937.
  3. ↑ "Introducing Molecular Therapy— Methods & Clinical Development". Molecular Therapy. Archived from the original on 29 September 2013.
  4. ↑ Dr. Malcolm Brenner's Faculty Page, Texas Children's Cancer Center, retrieved 13 December 2013
  5. ↑ "ESGCT Awards".
  6. ↑ "Malcolm K. Brenner Receives the 2020 ISCT Career Achievement Award in Cell & Gene Therapy: Flexibility and Resilience Leads to Excellence in Clinical Research and Mentorship".
  1. Malcolm K. Brenner (22 September 2005). Allogeneic Stem Cell Transplantation and Other Immunotherapies for Pediatric Malignancies. Archived from the original on 14 April 2013. Retrieved 15 January 2024.
  2. "Giant Step for Gene Therapy". Time Magazine. Initial work on gene marking. 24 September 1990. Archived from the original on 13 April 2009. Retrieved 30 May 2007.
  3. "Center for Cell and Gene Therapy". Retrieved 30 May 2007.


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