Malcolm VandenBurg is a British doctor involved in drug research, sexual health, medicolegal advice and stress management.[1]

Medical career

VandenBurg qualified in St Bartholomew's Hospital in 1973 with a BSc in Physiology.

He lectured in medicine, as an Honorary Senior Registrar at the London Hospital and as an Honorary Lecturer in Clinical Pharmacology at St Bartholomew's Hospital

VandenBurg is a Fellow of the Royal College of Physicians, the American College of Clinical Pharmacology and the Faculty of Pharmaceutical Medicine

He established the London Hospital Hypertension Clinic in 1975.[2]

Research

VandenBurg was director of cardiovascular research, Old Church Hospital Romford (1984–1996) and director of clinical research at Merck Sharpe & Dohme (1980–1984)

In 1996 he was appointed president and chief executive officer of global research consultancy IBRD – Rostrum Inc.[3]

VandenBurg has coordinated drug development programmes for over 30 pharmaceutical products and has over 100 publications in the field of clinical research. [2]

Medicolegal Work

VandenBurg is a registered expert witness[4] who has given medicolegal advice to courts, authorities and media in a number of high-profile cases.[5]

He has written in the BMJ about the medicolegal implications of newer SSRIs[6] and of driving while under the influence of cannabis[7]

VandenBurg was an expert witness in the case of the Death of Sean Rigg in police custody in 2008.[4] He also advised the Northern Ireland Prisoner Ombudsman on the deaths of Aaron Hogg in Maghaberry Prison in 2011.[8] and Frances McKeown in Hydebank Wood Prison,[9] both in 2011.

VandenBurg advised the UK press on the use of propofol in the Death of Michael Jackson.[10][11]

Key Publications

  • Johnson, P; Andrews, DC; Wells, S; De Lusignan, S; Robinson, J; Vandenburg, M (2001). "The use of a new continuous wireless cardiorespiratory telemonitoring system by elderly patients at home". Journal of Telemedicine and Telecare. 7 Suppl 1 (5): 76–7. doi:10.1258/1357633011936831. PMID 11576502.
  • Dews, I; Vandenburg, M (2001). "A 24-week dose-titration study of the angiotensin-converting enzyme inhibitor imidapril in the treatment of mild-to-moderate essential hypertension in the elderly". The Journal of International Medical Research. 29 (2): 100–7. doi:10.1177/147323000102900206. PMID 11393342. S2CID 25326174.
  • Vandenburg, MJ; Mackay, EM; Dews, I; Pullan, T; Brugier, S (March 1994). "Dose finding studies with imidapril--a new ACE inhibitor". British Journal of Clinical Pharmacology. 37 (3): 265–72. doi:10.1111/j.1365-2125.1994.tb04274.x. PMC 1364758. PMID 8198936.
  • Vandenburg, MJ; Allen, ME (January 1994). "Good clinical practice--a question of balance". British Journal of Clinical Pharmacology. 37 (1): 101–2. doi:10.1111/j.1365-2125.1994.tb04250.x. PMC 1364721. PMID 8148212.
  • Vandenburg, MJ; Stephens, JD; Resplandy, G; Dews, IM; Robinson, J; Desche, P (February 1993). "Digoxin pharmacokinetics and perindopril in heart failure patients". Journal of Clinical Pharmacology. 33 (2): 146–9. doi:10.1002/j.1552-4604.1993.tb03935.x. PMID 8440763. S2CID 31434688.
  • Allen, ME; Vandenburg, MJ (May 1992). "Good clinical practice: rules, regulations and their impact on the investigator". British Journal of Clinical Pharmacology. 33 (5): 463–5. doi:10.1111/j.1365-2125.1992.tb04071.x. PMC 1381430. PMID 1524957.
  • Wight, LJ; VandenBurg, MJ; Potter, CE; Freeth, CJ (1992). "A large scale comparative study in general practice with nitroglycerin spray and tablet formulations in elderly patients with angina pectoris". European Journal of Clinical Pharmacology. 42 (3): 341–2. doi:10.1007/bf00266360. PMID 1577055. S2CID 6916899.
  • Dews, IM; VandenBurg, MJ; Pullan, TR (December 1991). "A randomized crossover study of the blood pressure effects of tobacco and non-tobacco cigarettes". Journal of Hypertension Supplement. 9 (6): S120–1. doi:10.1097/00004872-199112006-00044. PMID 1818907.
  • Robinson, P; Vandenburg, M; Dews, I (2 November 1991). "Informed consent". BMJ (Clinical Research Ed.). 303 (6810): 1138. doi:10.1136/bmj.303.6810.1138. PMC 1671252. PMID 1747598.
  • Dews, IM; Vandenburg, MJ (13 April 1991). "Preventing fraud". BMJ (Clinical Research Ed.). 302 (6781): 907. doi:10.1136/bmj.302.6781.907-a. PMC 1669231. PMID 1859564.
  • Walker, JW; VandenBurg, MJ; Currie, WJ (1984). "Differential efficacy of two non-steroidal anti-inflammatory drugs in the treatment of sports injuries". Current Medical Research and Opinion. 9 (2): 119–23. doi:10.1185/03007998409109569. PMID 6544198.
  • Hayes, TB; Fyvie, A; Janke, PG; Vandenburg, MJ; Currie, WJ (March 1984). "Sulindac versus ibuprofen in sprains and strains". British Journal of Sports Medicine. 18 (1): 30–3. doi:10.1136/bjsm.18.1.30. PMC 1858854. PMID 6372927.
  • Cooper, WD; Currie, WJ; Vandenburg, MJ (March 1983). "The influence of physicians' instructions on the outcome of antihypertensive therapy". The British Journal of Clinical Practice. 37 (3): 99–103. PMID 6882631.

Books

  • Positive Under Pressure jointly authored with Gael Lindenfield, published by Avenue Books (24 April 2006)
  • Dilemmas and Solutions in Global Drug Development, published by Brookwood Medical Publications (January 2003)
  • Good Clinical Practice for Investigators, ROSTRUM Publications (July 1990)

References

  1. ↑ Janes, Cath (6 August 2009). "A controversial career". Careers. BMJ: b3072. doi:10.1136/bmj.b3072. S2CID 79577367.
  2. 1 2 Stuart R. Walker, ed. (1993). Quality of life assessment : key issues in 1990s. Dordrecht u.a.: Kluwer. pp. xv–xvi. ISBN 978-0-7923-8991-0.
  3. ↑ "The Pharma Letter".
  4. 1 2 "Death of Sean Rigg" (PDF). IPCC. Archived from the original (PDF) on 24 August 2012. Retrieved 5 December 2012.
  5. ↑ "Man disabled by MMR vaccine awarded £90,000 after 13-year fight". The Telegraph. Archived from the original on 31 August 2010.
  6. ↑ "Newer antidepressants for the treatment of depression in ad". The BMJ. 17 November 2018.
  7. ↑ "Acute cannabis consumption and motor vehicle collision risk: systematic review of observational studies and meta-analysis". The BMJ. 17 November 2018.
  8. ↑ "Report by The Prisoner Ombudsman into the circumstances surrounding the death of Aaron Hogg" (PDF). Northern Ireland Prisoner Ombudsman.
  9. ↑ "Report by The Prisoner Ombudsman into the circumstances surrounding the death of Frances McKeown" (PDF). Northern Ireland Prisoner Ombudsman.
  10. ↑ "Sedative at centre of Jackson probe". Daily Express.
  11. ↑ "Sedative at centre of Michael Jackson 'homicide' probe". The London Evening Standard.
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