First edition

Malignant: How Bad Policy and Bad Evidence Harm People with Cancer is a nonfiction book by Vinay Prasad, published in 2020 by Johns Hopkins University Press.[1]

Content

The book delves into cancer policy, oncological drug regulation, and clinical trial design, examining how many marginal and unproven cancer therapies are pushed to market on the basis of hype and bias.

Reviews

According to Benjamin Chin Yee, who wrote an in-depth review of Malignant, "Prasad does not shy away from controversy, and lays out his argument in lucid, readable prose."[2] Tahla Burki writes in the Lancet Haematology, "Prasad outlines how the US Food and Drug Administration (FDA) approves cancer therapies on the basis of arbitrarily assigned surrogate endpoints that typically have no bearing on overall survival or quality of life. He examines how a complex web of conflicts-of-interests pollutes policy debates and expert recommendations, and how studies ask irrelevant questions in unrepresentative patient populations."[3] Prasad has appeared on many podcasts to discuss Malignant, such as EconTalk with Russ Roberts[4] and Oncology Overdrive with Shikha Jain.[4] These discussions examine the current state of cancer policy and the ways in which physicians and patients can benefit from appropriate solutions.

References

  1. ↑ Lin, Kenneth W. (October 12, 2020). "'Malignant' Takes a Critical Look at Cancer Policy". Medscape. Retrieved 2021-09-23.
  2. ↑ Chin-Yee, Benjamin (19 March 2021). "Malignant by Vinay Prasad: Oncology's Leading Gadfly". Philosophy of Medicine. 2 (1). doi:10.5195/philmed.2021.44. S2CID 234822888.
  3. ↑ Burki, Talha K (May 2020). "Shaping cancer policy to work towards the interests of patients". The Lancet Haematology. 7 (5): e369. doi:10.1016/S2352-3026(20)30119-8. PMID 32359451. S2CID 218490117.
  4. 1 2 "Vinay Prasad on Cancer Drugs, Medical Ethics, and Malignant".
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