Maria K. Lehtinen
Alma materHarvard University (PhD)
AwardsNYSCF Robertson Neuroscience Investigator
Scientific career
FieldsNeuroscience
InstitutionsHarvard Medical School
Websitewww.childrenshospital.org/research/labs/lehtinen-laboratory

Maria K. Lehtinen is a neuroscientist and Associate Professor at Harvard Medical School. She is a New York Stem Cell Foundation Robertson Neuroscience Investigator[1][2] and holds the Hannah C. Kinney, MD Chair in Pediatric Pathology Research at Boston Children's Hospital.[3] Her research focuses on cerebrospinal fluid-based signaling in the central nervous system.

Education and Training

Lehtinen did her undergraduate studies at University of Pennsylvania.[4] She then received her PhD in Neurobiology from Harvard University working in the laboratory of Azad Bonni. Her graduate work elucidating the biological mechanisms of oxidative stress has been cited over 700 times.[5]

Lehtinen did a postdoctoral fellowship in the laboratory of Anna-Elina Lehesjoki at the University of Helsinki in Finland where she discovered a physiological mechanism underlying progressive myoclonus epilepsy.[6] She then continued her postdoctoral work with Christopher A. Walsh at Boston Children's Hospital, discovering that cerebrospinal fluid (CSF) affects the proliferation of neural progenitor cells during brain development.[7]

Career and Research

In 2010, Lehtinen received a prestigious K99/R00 NIH Pathway to Independence award from the National Institute of Neurological Disorders and Stroke.[8] This award funded her transition from postdoctoral fellow to assistant professor as she launched her independent laboratory at Boston Children's Hospital studying CSF-mediated signaling during development.

Lehtinen's work has shed light on several crucial aspects of biology. Her early groundbreaking work demonstrated formerly unrecognized spatial heterogeneity in the choroid plexus.[9] She has made several discoveries on the mechanisms of brain development,[10][11] and how that development is regulated by amniotic fluid and CSF.[12] Her work has also identified mechanistic underpinnings of developmental abnormalities including choroid plexus and ciliary body tumorigenesis [13] and microcephaly in LIG4 syndrome[14]

Publications

  • Maria K Lehtinen; Zengqiang Yuan; Peter R Boag; et al. (June 1, 2006). "A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span". Cell. 125 (5): 987–1001. doi:10.1016/J.CELL.2006.03.046. ISSN 0092-8674. PMID 16751106. Wikidata Q24338599.
  • Maria K Lehtinen; Mauro W Zappaterra; Xi Chen; et al. (March 1, 2011). "The cerebrospinal fluid provides a proliferative niche for neural progenitor cells". Neuron. 69 (5): 893–905. doi:10.1016/J.NEURON.2011.01.023. ISSN 0896-6273. PMC 3085909. PMID 21382550. Wikidata Q34169014.
  • Yoshiyuki Konishi; Maria Lehtinen; Nicole Donovan; Azad Bonni (May 1, 2002). "Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery". Molecular Cell. 9 (5): 1005–1016. doi:10.1016/S1097-2765(02)00524-5. ISSN 1097-2765. PMID 12049737. S2CID 18979336. Wikidata Q44017737.

Awards and honors

Lehtinen was a recipient of the 2017 Presidential Early Career Award for Scientists and Engineers.[15]

References

  1. ↑ "Robertson Neuroscience Investigators Archives". NYSCF.
  2. ↑ "NYSCF announces $9 million in grant awards to 6 new NYSCF -- Robertson Investigators". EurekAlert!. Retrieved March 7, 2020.
  3. ↑ "Maria K. Lehtinen, PhD | Researcher | Boston Children's Hospital". www.childrenshospital.org. Retrieved March 7, 2020.
  4. ↑ "Lehtinen Lab Members | Boston Children's Hospital". www.childrenshospital.org. Retrieved March 7, 2020.
  5. ↑ Lehtinen, Maria K.; Yuan, Zengqiang; Boag, Peter R.; Yang, Yue; Villén, Judit; Becker, Esther B. E.; DiBacco, Sara; Iglesia, Núria de la; Gygi, Steven; Blackwell, T. Keith; Bonni, Azad (June 2, 2006). "A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span". Cell. 125 (5): 987–1001. doi:10.1016/j.cell.2006.03.046. ISSN 0092-8674. PMID 16751106. S2CID 14496749.
  6. ↑ Lehtinen, M. K.; Tegelberg, S.; Schipper, H.; Su, H.; Zukor, H.; Manninen, O.; Kopra, O.; Joensuu, T.; Hakala, P.; Bonni, A.; Lehesjoki, A.-E. (May 6, 2009). "Cystatin B Deficiency Sensitizes Neurons to Oxidative Stress in Progressive Myoclonus Epilepsy, EPM1". Journal of Neuroscience. 29 (18): 5910–5915. doi:10.1523/JNEUROSCI.0682-09.2009. ISSN 0270-6474. PMC 2694495. PMID 19420257.
  7. ↑ Lehtinen, Maria K.; Zappaterra, Mauro W.; Chen, Xi; Yang, Yawei J.; Hill, Anthony D.; Lun, Melody; Maynard, Thomas; Gonzalez, Dilenny; Kim, Seonhee; Ye, Ping; D'Ercole, A. Joseph (March 2011). "The Cerebrospinal Fluid Provides a Proliferative Niche for Neural Progenitor Cells". Neuron. 69 (5): 893–905. doi:10.1016/j.neuron.2011.01.023. PMC 3085909. PMID 21382550.
  8. ↑ "Maria Lehtinen | Harvard Catalyst Profiles | Harvard Catalyst". connects.catalyst.harvard.edu. Retrieved April 12, 2020.
  9. ↑ Lun, Melody P.; Johnson, Matthew B.; Broadbelt, Kevin G.; Watanabe, Momoko; Kang, Young-Jin; Chau, Kevin F.; Springel, Mark W.; Malesz, Alexandra; Sousa, André M. M.; Pletikos, Mihovil; Adelita, Tais (March 25, 2015). "Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production". The Journal of Neuroscience. 35 (12): 4903–4916. doi:10.1523/JNEUROSCI.3081-14.2015. ISSN 1529-2401. PMC 4389594. PMID 25810521.
  10. ↑ Chau, Kevin F.; Shannon, Morgan L.; Fame, Ryann M.; Fonseca, Erin; Mullan, Hillary; Johnson, Matthew B.; Sendamarai, Anoop K.; Springel, Mark W.; Laurent, Benoit; Lehtinen, Maria K. (May 10, 2018). "Downregulation of ribosome biogenesis during early forebrain development". eLife. 7. doi:10.7554/eLife.36998. ISSN 2050-084X. PMC 5984036. PMID 29745900.
  11. ↑ Smith, Richard S.; Kenny, Connor J.; Ganesh, Vijay; Jang, Ahram; Borges-Monroy, Rebeca; Partlow, Jennifer N.; Hill, R. Sean; Shin, Taehwan; Chen, Allen Y.; Doan, Ryan N.; Anttonen, Anna-Kaisa (September 5, 2018). "Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development". Neuron. 99 (5): 905–913.e7. doi:10.1016/j.neuron.2018.07.052. ISSN 1097-4199. PMC 6226006. PMID 30146301.
  12. ↑ Chau, Kevin F.; Springel, Mark W.; Broadbelt, Kevin G.; Park, Hye-Yeon; Topal, Salih; Lun, Melody P.; Mullan, Hillary; Maynard, Thomas; Steen, Hanno; LaMantia, Anthony S.; Lehtinen, Maria K. (December 21, 2015). "Progressive Differentiation and Instructive Capacities of Amniotic Fluid and Cerebrospinal Fluid Proteomes following Neural Tube Closure". Developmental Cell. 35 (6): 789–802. doi:10.1016/j.devcel.2015.11.015. ISSN 1878-1551. PMC 4691285. PMID 26702835.
  13. ↑ Shannon, Morgan L.; Fame, Ryann M.; Chau, Kevin F.; Dani, Neil; Calicchio, Monica L.; Géléoc, Gwenaelle S.; Lidov, Hart G. W.; Alexandrescu, Sanda; Lehtinen, Maria K. (June 2018). "Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors". The American Journal of Pathology. 188 (6): 1334–1344. doi:10.1016/j.ajpath.2018.02.009. ISSN 1525-2191. PMC 5971223. PMID 29545198.
  14. ↑ Lun, Melody P.; Shannon, Morgan L.; Keles, Sevgi; Reisli, Ismail; Luche, Nicole; Ryan, Douglas; Capuder, Kelly; Notarangelo, Luigi D.; Lehtinen, Maria K. (December 2019). "Spatiotemporal Gradient of Cortical Neuron Death Contributes to Microcephaly in Knock-In Mouse Model of Ligase 4 Syndrome". The American Journal of Pathology. 189 (12): 2440–2449. doi:10.1016/j.ajpath.2019.08.010. ISSN 1525-2191. PMC 6897336. PMID 31541646.
  15. ↑ "President Obama Honors Federally-Funded Early-Career Scientists". January 9, 2017. Retrieved May 28, 2022.
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