MassMatrix is a mass spectrometry data analysis software that uses a statistical model to achieve increased mass accuracy over other database search algorithms.[1] This search engine is set apart from others dues to its ability to provide extremely efficient judgement between true and false positives for high mass accuracy data that has been obtained from present day mass spectrometer instruments. It is useful for identifying disulphide bonds in tandem mass spectrometry data.[2] This search engine is set apart from others due to its ability to provide extremely efficient judgement between true and false positives for high mass accuracy data that has been obtained from present day mass spectrometer instruments.[3]

References

  1. ↑ Xu H, Zhang L, Freitas MA (January 2008). "Identification and characterization of disulfide bonds in proteins and peptides from tandem MS data by use of the MassMatrix MS/MS search engine". Journal of Proteome Research. 7 (1): 138–44. doi:10.1021/pr070363z. PMC 2749473. PMID 18072732.
  2. ↑ Xu H, Freitas MA (July 2008). "Monte carlo simulation-based algorithms for analysis of shotgun proteomic data". Journal of Proteome Research. 7 (7): 2605–15. doi:10.1021/pr800002u. PMC 2749500. PMID 18543962.
  3. ↑ Xu, Hua; Hsu, Pang-Hung; Zhang, Liwen; Tsai, Ming-Daw; Freitas, Michael A. (2010-07-02). "Database Search Algorithm for Identification of Intact Cross-Links in Proteins and Peptides Using Tandem Mass Spectrometry". Journal of Proteome Research. 9 (7): 3384–3393. doi:10.1021/pr100369y. ISSN 1535-3893. PMC 4141472. PMID 20469931.


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