A matrix metalloproteinase inhibitor (MMPI, INN stem –mastat[1]) inhibits matrix metalloproteinases. Because they inhibit cell migration, they have antiangiogenic effects. They may be both endogenous and exogenous.

The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases (TIMPs). There are also cartilage-derived angiogenesis inhibitors.

Exogenous matrix metalloproteinase inhibitors were developed as anticancer drugs.[2] Examples include:

Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae, and bacteria.[3]

See also

References

  1. ↑ "The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances" (PDF). World Health Organization. Retrieved 5 November 2016.
  2. ↑ Coussens, L. M. (2002). "Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations". Science. 295 (5564): 2387–2392. Bibcode:2002Sci...295.2387C. doi:10.1126/science.1067100. ISSN 0036-8075. PMID 11923519. S2CID 19944201.
  3. ↑ Noel Vinay Thomas; Se Kwon Kim (2010). "Metalloproteinase Inhibitors Stts and Scope from Marine Organisms". Biochemistry Research International. 2010: 845975. doi:10.1155/2010/845975. PMC 3004377. PMID 21197102.
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