Morelia-Salamanca

Highway 43D begins at a junction with Mexican Federal Highway 15D and Highway 43 at Cuitzeo, north of Morelia. It immediately crosses Lake Cuitzeo, and on the north side is the first toll plaza and an exit to Cuitzeo. Before entering the road crosses over Highway 43, partially crossing over the lake again, before continuing past a second toll plaza, known as La Cinta, and toward its next interchange and toll plaza, offering access to Uriangato via Highway 43. Highway 43D turns northwest after this interchange, skirting Lake Yuriria, before adjusting north. The next interchange and toll plaza are at Valle de Santiago.

The next and last interchange and toll plaza are at Valtierrilla, serving access to the town and Mexican Federal Highway 45 west to Salamanca. The Morelia-Salamanca stretch, with a length of 107.95 kilometres (67.08 mi), then ends at Mexican Federal Highway 45D west of Cerro Gordo; both the intersecting highway and the highway continuing forward (Salamanca-León) are signed Highway 45D.