Minamitakaki (南高来郡, Minami-Takaki-gun, English: South Takaki District) was a district located in Nagasaki Prefecture, Japan.

Minamitakaki District is now equivalent to the cities of Shimabara, Unzen, and Minami-Shimabara.

As of 2003, the district had an estimated population of 117,639 and a density of 293.97 persons per km². The total area was 400.18 km².

Former towns and villages

• Aino
• Ariake
• Arie
• Azuma
• Chijiwa
• Fukae
• Futsu
• Kazusa
• Kita-Arima
• Kuchinotsu
• Kunimi
• Minami-Arima
• Minami-Kushiyama
• Mizuho
• Nishi-Arie
• Obama

Mergers

• On October 11, 2005 - the towns of Aino, Azuma, Chijiwa, Kunimi, Minami-Kushiyama, Mizuho and Obama were merged to create the city of Unzen.
• On January 1, 2006 - the town of Ariake were merged into the expanded city of Shimabara.
• On March 31, 2006 - the towns of Arie, Fukae, Futsu, Kazusa, Kita-Arima, Kuchinotsu, Minami-Arima and Nishi-Arie were merged to create the city of Minami-Shimabara. Minamitakaki District was dissolved as a result of this merger.