| NCDN | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | NCDN, neurochondrin, NEDIES | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 608458 MGI: 1347351 HomoloGene: 8064 GeneCards: NCDN | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Neurochondrin (also known as its murine homologue, Norbin) is a protein that in humans is encoded by the NCDN gene.[5][6]
This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein norbin that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.[6]
Norbin can modulate signaling activity and expression of metabotropic glutamate receptor 5; modulating mice with targeted deletion of NCDN in the brain have phenotypic traits usually found in the rodent models of schizophrenia, including disruptions in prepulse inhibition.[7] Furthermore, norbin protein expression is altered in the schizophrenia brain.[8] Norbin also plays a role in regulating antimicrobial responses in neutrophils.[9]
Neurochondrin proteins induce hydroxyapatite resorptive activity in bone marrow cells resistant to bafilomycin A1, an inhibitor of macrophage- and osteoclast-mediated resorption. Expression of the gene is localised to chondrocyte, osteoblast, and osteocyte in the bone and to the hippocampus and Purkinje cell layer of cerebellum in the brain.[10]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000020129 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028833 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Istvánffy R, Vogt Weisenhorn DM, Floss T, Wurst W (April 2004). "Expression of neurochondrin in the developing and adult mouse brain". Development Genes and Evolution. 214 (4): 206–209. doi:10.1007/s00427-004-0396-2. PMID 15007648. S2CID 45134242.
- 1 2 "Entrez Gene: NCDN neurochondrin".
- ↑ Wang H, Westin L, Nong Y, Birnbaum S, Bendor J, Brismar H, et al. (December 2009). "Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling". Science. 326 (5959): 1554–1557. Bibcode:2009Sci...326.1554W. doi:10.1126/science.1178496. PMC 2796550. PMID 20007903.
- ↑ Matosin N, Fernandez-Enright F, Fung SJ, Lum JS, Engel M, Andrews JL, et al. (July 2015). "Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation". Acta Neuropathologica. 130 (1): 119–129. doi:10.1007/s00401-015-1411-6. PMID 25778620. S2CID 12360955.
- ↑ Pantarelli C, Pan D, Chetwynd S, Stark AK, Hornigold K, Machin P, et al. (August 2021). "The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection". Blood Advances. 5 (16): 3076–3091. doi:10.1182/bloodadvances.2020002782. PMC 8405187. PMID 34402884.
- ↑ Ishiduka Y, Mochizuki R, Yanai K, Takatsuka M, Nonomura T, Niida S, et al. (May 1999). "Induction of hydroxyapatite resorptive activity in bone marrow cell populations resistant to bafilomycin A1 by a factor with restricted expression to bone and brain, neurochondrin". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1450 (1): 92–98. doi:10.1016/s0167-4889(99)00039-7. PMID 10231559.
Further reading
- Dateki M, Horii T, Kasuya Y, Mochizuki R, Nagao Y, Ishida J, et al. (May 2005). "Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure". The Journal of Biological Chemistry. 280 (21): 20503–20508. doi:10.1074/jbc.M414033200. PMID 15790563.
- Mochizuki R, Dateki M, Yanai K, Ishizuka Y, Amizuka N, Kawashima H, et al. (October 2003). "Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality". Biochemical and Biophysical Research Communications. 310 (4): 1219–1226. doi:10.1016/j.bbrc.2003.09.153. PMID 14559245.
- Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, et al. (January 2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular Medicine. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.
- Ohoka Y, Hirotani M, Sugimoto H, Fujioka S, Furuyama T, Inagaki S (January 2001). "Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75". Biochemical and Biophysical Research Communications. 280 (1): 237–243. doi:10.1006/bbrc.2000.4080. PMID 11162505.
- Mochizuki R, Ishizuka Y, Yanai K, Murakami K, Koga Y, Fukamizu A (February 2000). "Corrigendum to 'Molecular cloning and expression of human neurochondrin-1 and -2'(1)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1490 (3): 367–368. doi:10.1016/s0167-4781(99)00236-5. PMID 10684983.
- Mochizuki R, Ishizuka Y, Yanai K, Koga Y, Fukamizu A, Murakami K (September 1999). "Molecular cloning and expression of human neurochondrin-1 and -2". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446 (3): 397–402. doi:10.1016/s0167-4781(99)00120-7. PMID 10524216.
- Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–39. doi:10.1093/dnares/5.1.31. PMID 9628581.
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