NDFIP2

NDFIP2
Identifiers
Aliases	NDFIP2, N4WBP5A, Nedd4 family interacting protein 2
External IDs	OMIM: 610041 MGI: 1923523 HomoloGene: 12636 GeneCards: NDFIP2
Gene location (Human)
Chr.	Chromosome 13 (human)
End	79,556,077 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	105,546,732 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sperm; ; pancreatic epithelial cell; ; Brodmann area 46; ; palpebral conjunctiva; ; jejunal mucosa; ; pons; ; endothelial cell; ; germinal epithelium; ; postcentral gyrus;
	Top expressed in
	habenula; ; medial vestibular nucleus; ; olfactory tubercle; ; submandibular gland; ; ventral tegmental area; ; pontine nuclei; ; lateral geniculate nucleus; ; left colon; ; globus pallidus; ; barrel cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; protein binding; WW domain binding;
Cellular component	cytoplasm; integral component of membrane; endosome; Golgi apparatus; multivesicular body membrane; intracellular membrane-bounded organelle; membrane; Golgi membrane; endoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; endosome membrane;
Biological process	negative regulation of gene expression; negative regulation of protein transport; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein ubiquitination; negative regulation of transporter activity; signal transduction; vacuolar transport; metal ion transport;
	Sources:Amigo / QuickGO
Orthologs
	54602
	76273
	ENSG00000102471
	ENSMUSG00000053253
	Q9NV92
	Q91ZP6
	NM_001161407; NM_019080; NM_001394685
	NM_001190989; NM_029561
	NP_001154879; NP_061953
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

NEDD4 family-interacting protein 2 is a protein that in humans is encoded by the NDFIP2 gene.^[5]^[6]^[7]

Interactions

NDFIP2 has been shown to interact with NEDD4.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102471 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053253 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
↑ Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, Korbmacher C, Kumar S (Aug 2002). "Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein". J Biol Chem. 277 (33): 29406–16. doi:10.1074/jbc.M203018200. PMID 12050153.
↑ "Entrez Gene: NDFIP2 Nedd4 family interacting protein 2".
↑ Cristillo AD, Nie Linghu, Macri Mirtha J, Bierer Barbara E (Sep 2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". J. Biol. Chem. 278 (36): 34587–97. doi:10.1074/jbc.M304723200. ISSN 0021-9258. PMID 12796489.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
Cristillo AD, Nie L, Macri MJ, Bierer BE (2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". J. Biol. Chem. 278 (36): 34587–97. doi:10.1074/jbc.M304723200. PMID 12796489.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Shearwin-Whyatt LM, Brown DL, Wylie FG, et al. (2005). "N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking". J. Cell Sci. 117 (Pt 16): 3679–89. doi:10.1242/jcs.01212. hdl:2440/9578. PMID 15252135.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102471 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053253 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10574461-5] Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.

[pmid12050153-6] Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, Korbmacher C, Kumar S (Aug 2002). "Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein". J Biol Chem. 277 (33): 29406–16. doi:10.1074/jbc.M203018200. PMID 12050153.

[entrez-7] "Entrez Gene: NDFIP2 Nedd4 family interacting protein 2".

[pmid12796489-8] Cristillo AD, Nie Linghu, Macri Mirtha J, Bierer Barbara E (Sep 2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". J. Biol. Chem. 278 (36): 34587–97. doi:10.1074/jbc.M304723200. ISSN 0021-9258. PMID 12796489.

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Interactions

References

Further reading