NLGN3
Identifiers
AliasesNLGN3, HNL3, neuroligin 3
External IDsOMIM: 300336 MGI: 2444609 HomoloGene: 23133 GeneCards: NLGN3
Orthologs
SpeciesHumanMouse
Entrez

54413

245537

Ensembl

ENSG00000196338

ENSMUSG00000031302

UniProt

Q9NZ94

Q8BYM5

RefSeq (mRNA)

NM_001166660
NM_018977
NM_181303
NM_001321276

NM_172932

RefSeq (protein)

NP_001160132
NP_001308205
NP_061850
NP_851820
NP_001160132.1

NP_766520

Location (UCSC)Chr X: 71.14 – 71.18 MbChr X: 100.34 – 100.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuroligin-3 is a protein that in humans is encoded by the NLGN3 gene.[5][6][7]

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism spectrum disorders (ASDs). Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196338 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031302 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.
  6. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  7. 1 2 "Entrez Gene: NLGN3 neuroligin 3".

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.