NLRP12

NLRP12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L6A, 4XHS
Identifiers
Aliases	NLRP12, CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2, NLR family, pyrin domain containing 12, NLR family pyrin domain containing 12
External IDs	OMIM: 609648 MGI: 2676630 HomoloGene: 16972 GeneCards: NLRP12
Gene location (Human)
Chr.	Chromosome 19 (human)
End	53,824,394 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	3,298,370 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; secondary oocyte; ; spongy bone; ; bone marrow cells; ; spleen; ; appendix; ; right lung; ; upper lobe of left lung; ; smooth muscle tissue;
	Top expressed in
	liver; ; morula; ; blastocyst; ; placenta; ; bone marrow; ; yolk sac; ; spleen; ; lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; cysteine-type endopeptidase activator activity involved in apoptotic process; ATP binding; protein binding;
Cellular component	cytoplasm; nucleus;
Biological process	dendritic cell migration; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of I-kappaB kinase/NF-kappaB signaling; activation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of Toll signaling pathway; signal transduction; negative regulation of NIK/NF-kappaB signaling; negative regulation of inflammatory response; cellular response to cytokine stimulus; negative regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of inflammatory response; negative regulation of protein autophosphorylation; positive regulation of MHC class I biosynthetic process; negative regulation of ERK1 and ERK2 cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of signal transduction; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	91662
	378425
	ENSG00000142405
	ENSMUSG00000078817
	P59046
	E9Q5R7
	NM_001277126; NM_001277129; NM_033297; NM_144687
	NM_001033431
	NP_001264055; NP_001264058; NP_653288
	NP_001028603
	Wikidata
View/Edit Human	View/Edit Mouse

NACHT, LRR and PYD domains-containing protein 12 is a protein that in humans is encoded by the NLRP12 gene.^[5]^[6]^[7]

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000142405 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078817 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
↑ Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.
1 2 "Entrez Gene: NLRP12 NLR family, pyrin domain containing 12".

Shami PJ, Kanai N, Wang LY, et al. (2001). "Identification and characterization of a novel gene that is upregulated in leukaemia cells by nitric oxide". Br. J. Haematol. 112 (1): 138–47. doi:10.1046/j.1365-2141.2001.02491.x. PMID 11167794. S2CID 44981142.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Williams KL, Taxman DJ, Linhoff MW, et al. (2003). "Cutting edge: Monarch-1: a pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes". J. Immunol. 170 (11): 5354–8. doi:10.4049/jimmunol.170.11.5354. PMID 12759408.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Williams KL, Lich JD, Duncan JA, et al. (2006). "The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals". J. Biol. Chem. 280 (48): 39914–24. doi:10.1074/jbc.M502820200. PMC 4422647. PMID 16203735.
Lich JD, Williams KL, Moore CB, et al. (2007). "Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes". J. Immunol. 178 (3): 1256–60. doi:10.4049/jimmunol.178.3.1256. PMID 17237370.
Arthur JC, Lich JD, Aziz RK, et al. (2007). "Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase". J. Immunol. 179 (9): 6291–6. doi:10.4049/jimmunol.179.9.6291. PMID 17947705.
Chen L, Wilson JE, Koenigsknecht MJ, et al. (2017). "NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth". Nature Immunology. 18 (5): 541–551. doi:10.1038/ni.3690. PMC 5395345. PMID 28288099.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000142405 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078817 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12563287-5] Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.

[pmid12019269-6] Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.

[entrez-7] 1 2 "Entrez Gene: NLRP12 NLR family, pyrin domain containing 12".

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NOD-like receptor family
CARD domain containing	NOD1/NLRC1 NOD2/NLRC2 NLRC3 NLRC4 NLRC5
Pyrin domain containing	NLRP1 NLRP2 NLRP3 NLRP4 NLRP5 NLRP6 NLRP7 NLRP8 NLRP9 NLRP10 NLRP11 NLRP12 NLRP13 NLRP14
Apoptosis inhibitory protein	NAIP
Family member X1	NLRX1

References

Further reading