NPLOC4

NPLOC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PJH
Identifiers
Aliases	NPLOC4, NPL4, NPL4 homolog, ubiquitin recognition factor
External IDs	OMIM: 606590 MGI: 2679787 HomoloGene: 5403 GeneCards: NPLOC4
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,648,465 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,328,534 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; stromal cell of endometrium; ; right coronary artery; ; islet of Langerhans; ; left ventricle; ; right adrenal gland; ; ascending aorta; ; left adrenal gland; ; sural nerve; ; monocyte;
	Top expressed in
	spermatocyte; ; cumulus cell; ; interventricular septum; ; ascending aorta; ; aortic valve; ; spermatid; ; supraoptic nucleus; ; seminiferous tubule; ; lip; ; somite;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin binding; protein binding; metal ion binding; ubiquitin protein ligase binding;
Cellular component	cytoplasm; cytosol; nuclear outer membrane-endoplasmic reticulum membrane network; endoplasmic reticulum; nucleus; UFD1-NPL4 complex; nucleoplasm; VCP-NPL4-UFD1 AAA ATPase complex;
Biological process	error-free translesion synthesis; retrograde protein transport, ER to cytosol; Golgi organization; ubiquitin-dependent ERAD pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of type I interferon production; negative regulation of RIG-I signaling pathway; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	55666
	217365
	ENSG00000182446
	ENSMUSG00000039703
	Q8TAT6
	P60670
	NM_017921; NM_001369698
	NM_001195023; NM_199469
	NP_060391; NP_001356627; NP_060391.2
	NP_001181952; NP_955763
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear protein localization protein 4 homolog is a protein that in humans is encoded by the NPLOC4 gene.^[5]^[6]^[7]

Interactions

NPLOC4 has been shown to interact with UFD1L.^[5]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182446 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039703 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Botta A, Tandoi C, Fini G, Calabrese G, Dallapiccola B, Novelli G (Sep 2001). "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)". Gene. 275 (1): 39–46. doi:10.1016/S0378-1119(01)00649-7. PMID 11574150.
↑ Meyer HH, Shorter JG, Seemann J, Pappin D, Warren G (Jun 2000). "A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways". EMBO J. 19 (10): 2181–92. doi:10.1093/emboj/19.10.2181. PMC 384367. PMID 10811609.
↑ "Entrez Gene: NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)".
↑ Lass A, McConnell E, Fleck K, Palamarchuk A, Wójcik C (Aug 2008). "Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD". Exp. Cell Res. 314 (14): 2715–23. doi:10.1016/j.yexcr.2008.06.008. PMID 18586029.

McConnell E, Lass A, Wójcik C (2007). "Ufd1-Npl4 is a negative regulator of cholera toxin retrotranslocation". Biochem. Biophys. Res. Commun. 355 (4): 1087–90. doi:10.1016/j.bbrc.2007.02.077. PMID 17331469.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000182446 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039703 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11574150-5] 1 2 Botta A, Tandoi C, Fini G, Calabrese G, Dallapiccola B, Novelli G (Sep 2001). "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)". Gene. 275 (1): 39–46. doi:10.1016/S0378-1119(01)00649-7. PMID 11574150.

[pmid10811609-6] Meyer HH, Shorter JG, Seemann J, Pappin D, Warren G (Jun 2000). "A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways". EMBO J. 19 (10): 2181–92. doi:10.1093/emboj/19.10.2181. PMC 384367. PMID 10811609.

[entrez-7] "Entrez Gene: NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)".

[pmid18586029-8] Lass A, McConnell E, Fleck K, Palamarchuk A, Wójcik C (Aug 2008). "Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD". Exp. Cell Res. 314 (14): 2715–23. doi:10.1016/j.yexcr.2008.06.008. PMID 18586029.

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Interactions

References

Further reading