Hepatitis C virus nonstructural protein 4A

HCV genome

Nonstructural protein 4A (NS4A) is a viral protein found in the hepatitis C virus. It acts as a cofactor for the enzyme NS3.^[1]

References

↑ Beld M, Penning M, van Putten M, et al. (October 1998). "Hepatitis C virus serotype-specific core and NS4 antibodies in injecting drug users participating in the Amsterdam cohort studies". J. Clin. Microbiol. 36 (10): 3002–6. doi:10.1128/JCM.36.10.3002-3006.1998. PMC 105101. PMID 9738057.

Viral proteins (early and late)

linear ds-DNA
(Duplodnaviria,
Varidnaviria)

VSPs:

capsid:	HHV capsid portal protein Herpesvirus glycoprotein B

VNPs:

VNPs:	B13R

VNPs:	E1A E1B

circular ds-DNA
(Duplodnaviria,
Varidnaviria?)

VSPs:	LMP-1 LMP-2
VNPs:	EBNA-1 EBNA-2 EBNA-3
ncRNA:	EBER

VNPs:	Early 35 kDa protein

other
(Riboviria,
Monodnaviria)

Polyomaviridae
(SV40, MPyV, MCPyV, HaPyV)
(non-enveloped circular ds-DNA)

VSPs:

capsid:	VP1 VP2 and VP3

VNPs:

oncoprotein:	STag MTag LTag (SV40 Tag)

Agnoprotein

Hepatitis B
(circular partially ds-DNA)

VSPs:	HBsAg HBcAg HBeAg
VNPs:	HBx Hepatitis B virus DNA polymerase

ds-RNA
(Riboviria)

Rotavirus
(Duplornaviricota)

VNPs:	NSP1 NSP2 NSP3 NSP4 NSP5 NSP6

Rhinov., Polio, Hep A,
etc. (Pisuviricota)

VNPs:	VPg

ss-RNA
positive-sense
(Riboviria)

Hepatitis C
(Kitrinoviricota)

VSPs:	viral envelope E1 E2
VNPs:	P7 NS2 NS3 NS4A NS4B NS5A NS5B

SARS-CoV-2
(Pisuviricota)

VSPs:	viral envelope Spike Envelope Membrane Nucleocapsid
VNPs:	ORF1ab 3C-like protease (NS5) ORF3a ORF3b ORF3c ORF3d ORF6 ORF7a ORF7b ORF8 ORF9b

ss-RNA
negative-sense
(Negarnaviricota)

Influenza virus

VSPs:

capsid:	matrix protein M1 protein viral envelope M2 protein
glycoprotein:	Influenza hemagglutinin Neuraminidase HA-tag

VNPs:

NS1

VSPs:

glycoprotein:	Parainfluenza hemagglutinin-neuraminidase

VSPs:

glycoprotein:	Mumps hemagglutinin-neuraminidase

VSPs:

glycoprotein:	Measles hemagglutinin

VSPs:

glycoprotein:	Respiratory syncytial virus G protein

Zaire ebolavirus

VSPs:

capsid:	matrix protein VP40 VP24

Indiana vesiculovirus

VSPs:

capsid:	matrix protein Vesiculovirus matrix proteins

Structure and genome of HIV

VSPs:	gag p24 pol Integrase Reverse transcriptase HIV-1 protease env gp120 gp41
VRAPs:	transactivators Tat Rev Vpr Nef Vif Vpu or Vpx

Multiple

- Rous sarcoma virus
- murine leukemia virus

oncoprotein:	Gag-onc fusion protein

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