NPAS4
Identifiers
AliasesNPAS4, Le-PAS, NXF, PASD10, bHLHe79, neuronal PAS domain protein 4
External IDsOMIM: 608554 MGI: 2664186 HomoloGene: 15333 GeneCards: NPAS4
Orthologs
SpeciesHumanMouse
Entrez

266743

225872

Ensembl

ENSG00000174576

ENSMUSG00000045903

UniProt

Q8IUM7

Q8BGD7

RefSeq (mRNA)

NM_178864
NM_001318804

NM_153553

RefSeq (protein)

NP_001305733
NP_849195

NP_705781

Location (UCSC)Chr 11: 66.42 – 66.43 MbChr 19: 5.03 – 5.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuronal PAS domain protein 4 is a protein that in humans is encoded by the NPAS4 gene.[5] The NPAS4 gene is a neuronal activity-dependent immediate early gene that has been identified as a transcription factor. The protein regulates the transcription of genes that control inhibitory synapse development, synaptic plasticity and most recently reported also behavior.[6]


Function

NXF is a member of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008].

Npas4 has been shown by Dr. Brenda Bloodgood to play critical roles in regulating the plasticity of inhibitory neurons. She found that Npas4 helps to regulate plasticity by orchestrating a redistribution of synaptic inputs, biasing them towards dendrites over neuronal cell bodies which increases dendritic plasticity.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000174576 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045903 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Neuronal PAS domain protein 4". Retrieved 2017-10-15.
  6. Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa K, Ahammad RU, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K (2019). "Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors". Cell Reports. 29 (10): 3235–3252.e9. doi:10.1016/j.celrep.2019.10.116. PMID 31801086.
  7. Bloodgood, Brenda L.; Sharma, Nikhil; Browne, Heidi Adlman; Trepman, Alissa Z.; Greenberg, Michael E. (2013-11-07). "The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition". Nature. 503 (7474): 121–125. doi:10.1038/nature12743. ISSN 1476-4687. PMC 4169177. PMID 24201284.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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