Nuclear groove

Nuclear grooves (arrows indicate one of them) in papillary thyroid cancer. H&E stain.

Cytopathology of papillary thyroid carcinoma, with typical features, with nuclear groove at bottom right. Pap stain.

A nuclear groove is an invagination of the nuclear envelope, in the longitudinal axis.^[1] It can be present in:

Thyroid neoplasms: It is a characteristic feature of papillary thyroid carcinoma, but has also been seen in other types of thyroid neoplasms, as well as in non-neoplastic thyroid lesions.^[1]
Ovarian tumors including Brenner tumors, adult granulosa cell tumors, and transitional cell tumors.^[1]
Breast carcinomas^[1]
Vaginal, cervical and/or endometrial neoplasms
Papillary neoplasms of several organs: papillary transitional cell carcinoma of the urinary bladder, papillary renal cell carcinoma, papillary endometrioid carcinoma of the prostate, in thymic carcinomas, and in non-epithelial tumors.

References

1 2 3 4 Batistatou, Anna; Scopa, Chrisoula D. (2008). "Review Articles: Pathogenesis and Diagnostic Significance of Nuclear Grooves in Thyroid and Other Sites". International Journal of Surgical Pathology. 17 (2): 107–110. doi:10.1177/1066896908316071. ISSN 1066-8969.

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