OTUD7B

OTUD7B
Identifiers
Aliases	OTUD7B, CEZANNE, ZA20D1, OTU deubiquitinase 7B
External IDs	OMIM: 611748 MGI: 2654703 HomoloGene: 10624 GeneCards: OTUD7B
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,010,726 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,068,446 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; sural nerve; ; secondary oocyte; ; corpus callosum; ; inferior ganglion of vagus nerve; ; muscle of leg; ; gastrocnemius muscle; ; subthalamic nucleus; ; stromal cell of endometrium; ; external globus pallidus;
	Top expressed in
	blood; ; retinal pigment epithelium; ; sciatic nerve; ; right lung lobe; ; spermatid; ; spermatocyte; ; triceps brachii muscle; ; aortic valve; ; substantia nigra; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; cysteine-type peptidase activity; zinc ion binding; metal ion binding; peptidase activity; K63-linked polyubiquitin modification-dependent protein binding; protein binding; thiol-dependent deubiquitinase; hydrolase activity; Lys48-specific deubiquitinase activity;
Cellular component	cytoplasm; nucleus; cytosol;
Biological process	mucosal immune response; negative regulation of protein localization to nucleus; protein K48-linked deubiquitination; protein deubiquitination involved in ubiquitin-dependent protein catabolic process; immune system process; negative regulation of transcription by RNA polymerase II; negative regulation of I-kappaB kinase/NF-kappaB signaling; proteolysis; negative regulation of interleukin-8 production; protein K63-linked deubiquitination; immune response; protein deubiquitination; protein K11-linked deubiquitination; adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	56957
	229603
	ENSG00000264522
	ENSMUSG00000038495
	Q6GQQ9
	B2RUR8
	NM_020205
	NM_001025613; NM_001025614
	NP_064590
	NP_001020784; NP_001020785
	Wikidata
View/Edit Human	View/Edit Mouse

OTU domain-containing protein 7B is a protein that in humans is encoded by the OTUD7B gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000264522 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038495 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ (Jul 2001). "Isolation and characterization of two novel A20-like proteins". Biochemical Journal. 357 (Pt 3): 617–23. doi:10.1042/0264-6021:3570617. PMC 1221992. PMID 11463333.
↑ "Entrez Gene: OTUD7B OTU domain containing 7B".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Evans PC, Ovaa H, Hamon M, et al. (2004). "Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity". Biochem. J. 378 (Pt 3): 727–34. doi:10.1042/BJ20031377. PMC 1224040. PMID 14748687.
Evans PC, Smith TS, Lai MJ, et al. (2003). "A novel type of deubiquitinating enzyme". Journal of Biological Chemistry. 278 (25): 23180–6. doi:10.1074/jbc.M301863200. PMID 12682062.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Heyninck K, Beyaert R (1999). "The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Letters. 442 (2–3): 147–50. doi:10.1016/S0014-5793(98)01645-7. PMID 9928991.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000264522 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038495 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11463333-5] Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ (Jul 2001). "Isolation and characterization of two novel A20-like proteins". Biochemical Journal. 357 (Pt 3): 617–23. doi:10.1042/0264-6021:3570617. PMC 1221992. PMID 11463333.

[entrez-6] "Entrez Gene: OTUD7B OTU domain containing 7B".

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References

Further reading